Comparative Histopathological Characterization of Prostate Cancer in Saudi Patients by Conventional and 2005 ISUP Modified Gleason Systems

Abstract

<b>Background:</b> The aim of this study was to compare the characterization of prostate cancer using theconventional and 2005 ISUP modified Gleason systems. Materials and <br/><b>Methods</b>: The study employed samplesfrom 40 prostate cancer patients with resection, biopsy and RP materials. The majority of cases (95%) comprisedadenocarcinoma of the prostate with a modified combined Gleason score of 7 in 20 of the cases (50%). <br/><b>Results</b>:Upgrading of Gleason scores to a score of 7 occurred in more than 45% of the cases. <br/><b>Conclusion</b>: The studysuccessfully showed that by the use of the 2005 ISUP modified Gleason system, score 6 cancers decreased from25% to 17.5% of cases, whereas score 7 cancers increased from 45% to 50%.