A Systematic Review of Cervical Cancer Incidence and Mortality in the Pacific Region

Abstract

This study provides the first systematic literature review of cervical cancer incidence and mortality as wellas human papillomavirus (HPV) genotype prevalence among women with cervical cancer in the Pacific Islandcountries and territories. The cervical cancer burden in the Pacific Region is substantial, with age standardizedincidence rates ranging from 8.2 to 50.7 and age standardized mortality rate from 2.7 to 23.9 per 100,000 womenper year. The HPV genotype distribution suggests that 70-80% of these cancers could be preventable by thecurrently available bi- or quadrivalent HPV vaccines. There are only few comprehensive studies examining theepidemiology of cervical cancer in this region and no published data have hitherto described the current cervicalcancer prevention initiatives in this region.