Influence of Chongcao Yigan Capsule on Function of Intestinal Flora and Chemoprevention for Patients with Chronic Hepatitis B-Induced Liver Fibrosis

Abstract

<br/><b>Objective</b>: Hapatitis B visus (CHB)-induced fibrosis is a precancerous condition of liver. To explore the influenceof Chongcao Preparation (Chongcao Yigan Capsule) on the function of intestinal flora and chemoprevention forpatients with CHB-induced liver fibrosis. <br/><b>Methods</b>: A total of 136 patients with CHB-induced liver fibrosis wererandomly divided into control group treated with lamivudine (LAM) and research group added with ChongcaoYigan Capsule for totally 48 weeks. The changes of intestinal flora, secretory immunoglobin A (SIgA), serumalbumin (ALB), prealbumin (PALB), IgA and IgG at different time points in both groups were observed. <br/><b>Results</b>:Before treatment, there was no significant difference between two groups in each index (P>0.05). After treatment,the intestinal flora were evidently optimized in research group than treatment before (P<0.05 or P<0.01), andwere apparently better than those in control group (P<0.05 or P<0.01); SIgA was obviously increased and ALB,PALB, IgA and IgG were markedly improved in research group than treatment before (P<0.05 or P<0.01), andwere significantly better than those in control group (P<0.05 or P<0.01). <br/><b>Conclusions</b>: Chongcao Yigan Capsulecould regulate the intestinal flora, increase SIgA, serum ALB and PALB concentrations and significantly improveserum IgA and IgG as well as strengthen the immunological function and autologous repair capacity of patientswith CHB-induced liver fibrosis.