Polymorphic Variation of Inflammation-related Genes and Risk of Non-Hodgkin Lymphoma for Uygur and Han Chinese in Xinjiang

Abstract

Polymorphisms of inflammation-related genes have been found to be associated with non-Hodgkin lymphoma(NHL) or some of its subtypes, but only a few relevant data have been reported in China. In this study, theSnapshot method was used to assess genetic variation; a total of 14 single nucleotide polymorphisms (SNPs) for 6inflammatory factors in 157 NHL cases (64 Uygur ethnic subjects, 93 Han Chinese) and 435 controls (231 Uygurand 204 Han Chinese) were studied from the Xinjiang province of China. Haplotype distribution was estimatedusing PHASE 2.3 software. Statistical differences in the genotype and haplotype frequencies between case andcontrol groups were also considered and estimated. For the Han population, the geneotype distributions for TNF-αrs1800629, TNF-αrs1800630, IL-6 rs1800795, IL-6 rs1800797, NF-KB1 rs1585215 and TLR-4 rs4986790 showedsignificant differences between the case and control groups (p<0.05). The TNF-α gene frequencies of ACG andCCA haplotypes in the cases were higher than in the controls (OR=2.45, 95% CI: 1.55-3.89, p=0.0002, OR=2.53,95% CI: 1.10-5.80, p=0.029, respectively), and the same findings were detected for TNF-β gene CA haplotype(OR=1.87, 95% CI: 1.21-2.90, p=0.0054). However, for the Uygur population, no such significant differenceswere detected within the gene-type distribution of the 14 SNPs. The TNF-α gene frequency of the CCA haplotypebetween the two groups (OR=1.98, 95% CI: 1.11-3.51, p=0.021) revealed a statistically significant difference.Our results showed that polymorphic variations of inflammation-related genes could be important to the NHLetiology of the Han population, and that these may only have limited influence on the Uygur population.