Cervical Pathology in Cytology-Negative/HPV-Positive Women: Results from Lampang Cancer Hospital, Thailand

Abstract

<b>Background:</b> To evaluate the cervical pathology of cytology-negative/high-risk human papillomavirus(HR-HPV) positive-women. Materials and <br/><b>Methods</b>: This study recruited 4,583 women aged 30-70 years whohad undergone cervical screening by liquid-based cytology and HR-HPV test (14 HR-HPV types) at LampangCancer Hospital during October 2012 to July 2013. Colposcopy was carried out in all women. <br/><b>Results</b>: Onehundred and ninety-two (4.19%) women were found to be cytology-negative/HR-HPV-positive. However, 23cases were excluded because of incomplete information, leaving 169 women for further analyses. Of these 169,45 (26.6%) were infected with HPV 16/18 and 49 (29.0%) with multiple genotypes of HR-HPV. Nineteen of 169(11.24%) women were found to have CIN 2-3. No women in the present study had AIS or invasive cervical lesions.Prevalence of CIN 2-3 among women infected with HPV 16/18 was 15.6% which was higher than the 9.68% inthose with non-HPV 16/18 oncogenic types. <br/><b>Conclusions</b>: Overall, 11% of cytology-negative/HR-HPV-positivewomen had significant cervical lesions. Risk of harboring such lesions was substantially increased among thosewho were HPV 16/18 positive.