GSTM1 Polymorphisms and Lung Cancer Risk in the Chinese Population: a Meta-Analysis Based on 47 Studies

Abstract

Although a number of studies have been conducted on the association between GSTM1 polymorphismsand lung cancer in China, this association remains elusive and controversial. To clarify the effects of GSTM1polymorphisms on the risk of lung cancer, a meta-analysis was performed in the Chinese population. Relatedstudies were identified from PubMed, Springer Link, Ovid, Chinese Wanfang Data Knowledge Service Platform,Chinese National Knowledge Infrastructure (CNKI), and Chinese Biology Medicine (CBM) up to 5th April 2014.A total of 45 articles (47 studies) including 6,623 cases and 7,865 controls were involved in this meta-analysis.Overall, a significant association (OR = 1.45, 95%CI: 1.32-1.60) was found between the null GSTM1 and lungcancer risk when all studies in Chinese population pooled into the meta-analysis. In subgroup analyses stratifiedby quality score, geographic area and source of controls, the same results were observed under all the models.This meta-analysis showed that the null GSTM1 may be a potential biomarker for lung cancer risk in Chinese,but further studies with gene-gene and gene-environment interactions are required for definite conclusions.