Screening of Precancerous Gastric Lesions by Serum Pepsinogen, Gastrin-17, Anti-Helicobacter Pylori and Anti-Caga Antibodies in Dyspeptic Patients over 50 years Old in Guilan Province, North of Iran

Abstract

<b>Background:</b> The aim of this study was to investigate the value of serum gastric markers to differentiatebetween patients with precancerous lesions and nonatrophic chronic gastritis. Materials and <br/><b>Methods</b>: Serumsamples of 128 patients with dyspepsia who were candidates for endoscopic examination were tested forpepsinogen (PG I and PG II), PG I/II ratio, gastrin 17(G-17), anti-Helicobacter pylori (anti-H pylori ) and anti-CagA antibodies. Two sample t-tests, chi-square tests and Pearson’s correlation analyses were used for analysisusing SPSS (version 20). <br/><b>Results</b>: PGI, PG I/II ratio values were decreased significantly in the precancerouslesion group (0.05, 0.001 respectively). The frequency of H pylori infection was significantly (p=0.03) differentbetween the two groups ofthe study. <br/><b>Conclusions</b>: We suggest PGI and the PG I/II ratio as valuable markersfor screening of premalignant gastric lesions.