Risk Factors of Lymph Node Metastases with Endometrial Carcinoma

Abstract

<b>Background:</b> The purpose of this study was to investigate and evaluate risk factors for lymph node metastases (LNM) in cases of endometrial cancer (EC). Materials and <br/><b>Methods</b>: A retrospective single institution analysis of patients surgically staged for EC at Ankara Oncology Education and Research Hospital from 1996 to 2010 was performed. Roles of prognostic factors, such as age, histological type, grade, depth of myometrial invasion, cervical involvement, peritoneal cytology, and tumor size, in the prediction of LNM were evaluated. Fisher’s exact test and logistic regression analysis were used to assess the effects of various factors on LNM. <br/><b>Results</b>: LNM was observed in 22 out of 247 patients (8.9%) and was significantly more common in the presence of tumors ofhigher grade, deep myometrial invasion (DMI), cervical involvement, size >2cm, and with positive peritoneal cytology. Logistic regression analysis revealed that DMI remained the only independent risk factor for LNM. NPV, PPV, sensitivity, and specificity for satisfying LNM risk were 98.0, 19.5, 86.3, and 65.3%, respectively for DMI. <br/><b>Conclusions</b>: The incidence of LNM is influenced independently by DMI. If data support a conclusion of DMI, LND should be seriously considered.