Clinical, Histopathological and Molecular Characteristics of Metastatic Breast Cancer in North-Eastern Kazakhstan: a 10 Year Retrospective Study

Abstract

Abstract<br />Background: Breast cancer (BC) is the top cancer among women worldwide and has been the most frequent<br />malignancy among Kazakhstan women over the past few decades. Information on clinical and histopathological<br />features of metastatic breast cancer (MBC), as well as the distribution of molecular subtypes is limited for Kazakh<br />people. Materials and Methods: The present observational retrospective study was carried out at Regional<br />Oncologic Dispensaries in the North-East Region of Kazakhstan (in Semey and Pavlodar cities). Сlinical and<br />histopathological data were obtained for a total of 570 MBC patients in the 10 year period from 2004-2013, for<br />whom data on molecular subtype were available for 253. Data from hospital charts were entered into SPSS 20<br />for analysis by one-way ANOVA analysis of associations of different variables with 1-5 year survival. Pearson<br />correlation and linear regression models were used to examine the relation between parameters with a p-value<br />< 0.05 considered statistically significant. Results: No significant relationships were evident between molecular<br />subtype and survival, site of metastases, stage or ethnicity. Young females below the age of 44 were slightly more<br />likely to have triple negative lesions. While the ductal type greatly predomonated, luminal A and B cases had a<br />higher percentage with lobular morphology. Conclusions: In this select group of metastatice brease cancer, no<br />links were noted for survival with molecular subtype, in contrast to much of the literature.