Clinical Manifestations and Imaging Characteristics of Gliomatosis Cerebri with Pathological Confirmation

Abstract

<br/><b>Objective</b>: To explore the clinical manifestations and imaging characteristics of gliomatosis cerebri to raisethe awareness and improve its diagnostic accuracy for patients. Materials and <br/><b>Methods</b>: Clinical data, imagingcharacteristics and pathological examination of 12 patients with GC from Jan., 2008 to Jan., 2012 were analyzedretrospectively. <br/><b>Results</b>: Patients with GC were clinically manifested with headache, vomiting, repeated seizures,fatigue and unstable walking, most of whom had more than 2 lesions involving in parietal lobe, followed bytemporal lobe, frontal lobe, periventricular white matter and corpus callosum. Magnetic resonance imaging (MRI)showed diffuse distribution, T1-weighted images (T1WI) with equal and low signals and T2-weighted images(T2WI) with bilateral symmetrical high diffuse signals. There was no reinforcement by enhancement scanningand signals were different in diffusion-weighted images (DWI). The higher the tumor staging, the stronger thesignals. Pathological examination showed neuroastrocytoma in which tumor tissues were manifested by infiltrativegrowth in blood vessels and around neurons. <br/><b>Conclusions</b>: In clinical diagnosis of GC, much attention should bepaid to the diffuse distribution of imaging characteristics, incomplete matching between clinical and imagingcharacteristics and confirmation by combining with histopathological examination.