Meta-analysis of the Relation Between the VDR Gene TaqⅠpolymorphism and Genetic Susceptibility to Prostate Cancer in Asian Populations

Abstract

<b>Background:</b> Polymorphisms of the Taq I gene have been associated with prostate cancer risk. <br/><b>Methods</b>:Weapplied a fixed-effects model to combine odds ratios (ORs) and 95% confidence intervals (95% CI). The Egger’stest was carried out to evaluate potential publication bias. <br/><b>Results</b>: A total of 10 case-control studies enrolling1,141 prostate cancer patients and 1,685 controls were included in this meta-analysis. Compared with the Tallele, the OR for the C allele was 0.81 (0.70-0.94). The ORs for CT and CC+CT genotypes were 0.86 (0.74-1.01)and 0.84 (0.73-0.97) compared to wide type genotype (homozygote TT). <br/><b>Conclusions</b>: The present meta-analysissuggests that the TF gene Taq I polymorphism may reduce the prostate cancer risk in Asian populations.