Lack of Sunlight Exposure Influence on Primary Glioblastoma Survival

Abstract

<b>Background:</b> The prognosis of primary glioblastoma (GBM) is poor. Approximately 2/3 of primary braintumor diagnoses are GBM, of which 95% are primary lesions. In this study, we aimed to evaluate whether moresunlight exposure has an effect on survival of patients with primary GBM. Materials and <br/><b>Methods</b>: A total of111 patients with primary GBM were enrolled from Kayseri in inner Anatolia which has a cold climate (n: 40)and Mersin in Mediterranean region with a warm climate and more sunlight exposure (n: 71). The patients withprimary GBM were divided into two groups as Kayseri and Mersin and compared for progression free survival(PFS) and overall survival (OS).<br/><b>Results</b>: The PFS values were 7.0 and 4.7 months for Kayseri and Mersin groups,respectively (p=0.10) and the repsective OS values were 13.3 and 9.4 months (p=0.13). We did not found anysignificant difference regarding age, sex, comorbidity, smoking, surgery, resurgery, adjuvant chemoradiotherapyand palliative chemotherapy between the groups. <br/><b>Conclusions</b>: We found that more sunlight exposure had noimpact on prognosis of patients with primary GBM, adding inconsistency to the literature about the relationshipbetween sunlight and GBM.