The Effect of Abraxane on Cell Kinetic Parameters of HeLa Cells

Abstract

Abraxane (nab-paclitaxel) is a member of the group of nano chemotherapeutics. It is approved for metastaticbreast cancer and non small cell lung cancer. Trials for several cancer types including gynecological cancers,head and neck, and prostatic cancer are being studied. In this study, the antiproliferative and apoptotic effect ofabraxane was evaluated on HeLa cell line originated from human cervix carcinoma. Three different doses (D1=10nM, D2=50 nM, D3=100 nM) were administered to HeLa cells for 24, 48 and 72 h. The 50 nM dose of abraxanedecreased DNA synthesis from 4.62-0.08%, mitosis from 3.36-1.89% and increased apoptosis from 10.6-30% at72 h. Additionally, tripolar metaphase plates were seen in mitosis preparations. In this study, abraxane effectedcell kinetic parameters significantly. This results are consistent with other studies in the literature.