Genetic Polymorphisms of TCF7L2 Lack Influence on Risk of the Polycystic Ovary Syndrome - a Systemic Analysis

Abstract

<b>Background:</b> The results of previous researches that analyzed the association between genetic polymorphismsof transcription factor-7-like 2 (TCF7L2, rs7903146) and polycystic ovary syndrome (PCOS) were conflicting.Current systematic analysis was conducted to re-explore this association using updated materials. Materials and<br/><b>Methods</b>: The PubMed database was used for data collection and the final search was conducted on January3, 2014. For TCF7L2 rs7903146, a non-signficiant slight increase in risk of PCOS development was observedunder three genetic models (dominant model: OR=1.06, 95%CI: 0.93-1.21, p>0.05; recessive model: OR=1.12,95%CI: 0.87-1.43, p> 0.05; homozygous model: OR=1.14, 95%CI: 0.87-1.47, p>0.05). In the subgroup analysesin Asian group, allele susceptibility of PCOS was calculated (allele model: OR=1.00, 95%CI: 0.74-1.35, p>0.05;dominant model: OR=0.98, 95%CI: 0.71-1.35, p>0.05; recessive model: OR=1.79, 95%CI: 0.33-9.84, p>0.05;homozygous model: OR=1.78, 95%CI: 0.32-9.80, p>0.05), the differences were again not statistically significant.<br/><b>Conclusions</b>: The findings of this systemic analysis suggest that the polymorphism of TCF7L2 rs7903146 maynot be associated with the susceptibility to PCOS.