One pot, Five-component Synthesis of Functionalized Piperidines Using Zn(OAc)2.2H2O as a Highly Efficient Catalyst

Abstract

A convenient synthetic route for the synthesis of biologically active functionalized piperidines using<br />Zn(OAc)2.2H2O as a highly efficient catalyst via five-component reaction of aromatic aldehydes,<br />anilines and β-ketoesters at ambient temperature has studied. Mild reaction conditions, simplicity of<br />operation and work-up procedures with no necessity of chromatographic purification steps, the<br />availability and easy to handle of this solid catalyst and good to high yields are the notable benefits<br />for the highly efficient synthesis of these products.<br /><br />