Lack of any Prognostic Value of Body Mass Index for Patients Undergoing Chemoradiotherapy for Esophageal Squamous Cell Carcinoma

Abstract

<b>Background:</b> The relationship between body mass index(BMI) and outcomes after chemoradiotherapy(CRT)has not been systematically addressed. The purpose of this study was to evaluate the effect of BMI on survivalin patients with esophageal squamous cell carcinoma (ESCC). Materials and <br/><b>Methods</b>: Sixty ESCC caseswere retrospectively reviewed in this study. Patient overall survival(OS) and disease-free survival (DFS) werecompared between two groups (BMI<24.00 kg/m2 and BMI≥24.00 kg/m2). <br/><b>Results</b>: There were 41 patients in thelow/normal BMI group (BMI<24.00 kg/m2) and 19 in the high BMI group (BMI≥24.00 kg/m2). No significantdifferences were observed in patient characteristics between these. We found no difference in 2-year OS and DFSassociated with BMI (p=0.763 for OS; p=0.818 for DFS) using the Kaplan-Meier method. Univariate analysisrevealed that higher clinical stage was prognostic for worse 2-year OS and DFS, metastasis for 2-year OS, lymphnode status for 2-year DFS, while age, gender, smoking, drinking, tumor location and BMI were not prognostic.There were no differences in the 2-year OS (hazard ratio=1.117; p=0.789) and DFS(hazard ratio=1.161; p=0.708)between BMI groups in multivariate analysis, whereas we found statistical differences in the 2-year OS and DFSassociated with clinical stage, gender and tumor infiltration (p<0.04), independent of age, smoking, drinking,tumor location, the status of lymph node metastases and BMI. <br/><b>Conclusions</b>: BMI was not associated with survivalin patients with ESCC treated with CRT as primary therapy. BMI should not be considered a prognostic factorfor patients undergoing CRT for ESCC.