The Effect of Gluten Free Diet on Components of Metabolic Syndrome: A Randomized Clinical Trial

Abstract

Background: This study aimed to assess the effects of Gluten free diet (GFD) on components of metabolic syndrome<br />(MES). Materials and Methods: In this randomized clinical trial, 50 subjects diagnosed with MES were randomly<br />divided into two groups (n=25). The first group received a GFD and the second group continued their regular diet.<br />Biochemical markers of MES and blood pressure were measured before and after 8-week intervention. Results: Forty<br />five subjects completed the study. A post-hoc comparison of the groups showed no effects of the GFD and control<br />diet on LDL cholesterol, total cholesterol, fasting insulin, HOMA-IR, systolic and diastolic blood pressure levels. The<br />GFD reduced fasting blood glucose, waist circumference (WC) and serum triglyceride concentration significantly<br />compared with the control diet (p<0.05). Conclusion: Short-term GFD reduced WC and improved glycemic control<br />and Triglyceride level in subjects with the metabolic syndrome.