Targeting Inflammation in Ovarian Cancer Through Natural Antioxidants, Potential Therapeutic and Preventive Implications

Abstract

There is extensive experimental data to support<br />the hypothesis that Reactive oxygen species (ROS)<br />accumulation is one of the major underlying mechanism<br />for carcinogenesis. Many forms of cancer are associated<br />with excessive accumulation of ROS including ovarian<br />cancer. It is now well understood that ROS production<br />should be scavenged by antioxidant defence mechanism/<br />DNA damage response of the human body to maintain<br />natural homeostasis (Kruk and Aboul-Enein, 2017).<br />Dysregulation of this balance leads to many inflammatory<br />diseases including the high risk of developing cancer. High<br />ROS concentration is associated with accumulation of<br />mutations which over the years leads to development of<br />cancer. Metabolic pathways including aerobic oxidation<br />in mitochondria respiratory are the major source of ROS<br />which in turn effect different signalling pathways (Kruk<br />and Aboul-Enein, 2017).