Role of CD135/CD117 on Prognosis and Overall Survival of Acute Myeloid Leukemia

Abstract

Background: The key proliferative RTKs for AML include c-KIT receptor (CD117) and FLT-3 receptor (CD135).<br />The aim of this study was to evaluate the CD135 and CD117 expression, co-expression of CD135 and CD117<br />(CD135+CD117), and the association of that co-expression with Event Free Survival (DFS) and Overall Survival (OS)<br />rates. Material and Methods: We analyzed CD117 and CD135 expression on AML blasts by flow cytometry and its<br />association with Event Free Survival (DFS) and Overall Survival (OS) in 66 AML treated on Hematology-Oncology<br />Research Center, Iran, Tabriz. Results: The overall OS and EFS were 50% and 80.3% respectively during our study.<br />Cox-regression analysis revealed that a poor EFS was significantly associated a low CD135 (HR 0.34, 95% CI<br />0.13–0.88, P = 0.02). Conclusion: This is the first study from Iran to show that the expressions of CD135, CD117 is<br />easily measurable by routine diagnostic flow-cytometry, and CD135+117 were not significantly associated with CR,<br />EFS, or OS .