Potential Diagnostic and Prognostic Value of Lymphocytic Mitochondrial DNA Deletion in Relation to Folic Acid Status in HCV-Related Hepatocellular Carcinoma
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Objective: We assessed the possibility of using mitochondrial (mt) DNA deletion as a molecular biomarker for disease progression in HCV-related hepatocellular carcinoma (HCC) and to identify its association with folic acid status. Methods: Serum folic acid and lymphocytic mtDNA deletions were assessed in 90 patients; 50 with HCC, 20 with liver cirrhosis (LC), and 20 with chronic hepatitis C (CHC) compared to 10 healthy control subjects. The diagnostic accuracy of mtDNA deletions frequency was evaluated using receiver-operating characteristic (ROC) curve analysis Survival analysis was performed using the Kaplan-Meier method. Differences in the survival rates were compared using log-rank test. Result: Our data revealed a significant elevation of mtDNA deletions frequency in the HCC group compared to the other groups (P-value groups (r= -0.094 and P-value P-value high frequency of mtDNA deletions (ΔCt ≥3.9; 5.7+ 0.6 months) was significantly shorter than those with low mtDNA deletions frequency (ΔCt P-value Conclusion: Our data provided an evidence that lymphocytic mtDNA deletion could be used as non-invasive biomarker for disease progression and patients' survival in HCV-related HCC. Also, our findings implied a causal relationship between the folate deficiency and the high mtDNA deletions frequency among Egyptian patients with HCV related HCC.
کلید واژگان
HCCmitochondrial DNA deletions
serum folic acid
Diagnosis
Prognosis
Cancer biology
شماره نشریه
9تاریخ نشر
2017-09-011396-06-10
ناشر
West Asia Organization for Cancer Prevention (WAOCP)سازمان پدید آورنده
Virology and Immunology Unit, Cancer Biology Department, National Cancer Institute, Cairo University, Cairo, Egypt.Endemic Medicine Department, Faculty of Medicine, Cairo University, Cairo, Egypt.
Endemic Medicine Department, Faculty of Medicine, Cairo University, Cairo, Egypt.
Endemic Medicine Department, Faculty of Medicine, Cairo University, Cairo, Egypt.
Virology and Immunology Unit, Cancer Biology Department, National Cancer Institute, Cairo University, Cairo, Egypt.
Virology and Immunology Unit, Cancer Biology Department, National Cancer Institute, Cairo University, Cairo, Egypt.
Virology and Immunology Unit, Cancer Biology Department, National Cancer Institute, Cairo University, Cairo, Egypt.
Department of public health, Faculty of Medicine, Cairo University, Cairo, Egypt.
Yassin Abdel Ghaffar Charity Hospital, Cairo University, Cairo, Egypt.
Endemic Medicine Department, Faculty of Medicine, Cairo University, Cairo, Egypt.
شاپا
1513-73682476-762X
