Magnetic Nanoporous Silica as Carriers for Ibuprofen: Adsorption and Release Study

Abstract

A carrier system based on nanoporous silica (SBA-15) with magnetic nanoparticles of CoFe2O4 was synthesized via the impregnation of cobalt salt, iron salt and citric acid with as-synthesized SBA-15. The obtained samples were characterized by small angle X-ray scattering (SAXS), N2 adsorption/desorption, scanning electron microscopy (SEM), vibrating sample magnetometer (VSM) and ultraviolet (UV) spectroscopy.The effect of magnetization on the drug release behavior of SBA-15 has been studied. Ibuprofen was chosen as a model drug. Drug release studies in simulated body fluid (SBF) at pH 7.4 showed that after 48 hours, the percentage of drug release through SBA-15 and magnetic SBA-15 could reach up to 80% and 20%, respectively. The obtained results reveal that the magnetization leads towards significant decrease of the drug release rate.