Volume 19, Issue 11
مرور بر اساس
ارسال های اخیر
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Ginkgetin induces apoptosis in 786-O cell line via suppression of JAK2-STAT3 pathway
(Mashhad University of Medical Sciences, 2016-11-01)Objective(s): Renal cell carcinoma (RCC) is insensitive to conventional chemotherapy. Ginkgetin effectively treats several carcinoma cells. However, little is known about effects of Ginkgetin on ...
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Protective effects of nimodipine and lithium against aluminum-induced cell death and oxidative stress in PC12 cells
(Mashhad University of Medical Sciences, 2016-11-01)Objective(s): The role of aluminum (Al) in the pathogenesis of neurodegenerative diseases has been implicated in several studies. However, the exact mechanisms of cytotoxic effects of Al have not ...
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Gene therapy based on interleukin-12 loaded chitosan nanoparticles in a mouse model of fibrosarcoma
(Mashhad University of Medical Sciences, 2016-11-01)Objective(s): Interleukin-12 (IL-12) as a cytokine has been proved to have a critical role in stimulating the immune system and has been used as immunotherapeutic agents in cancer gene therapy. ...
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The preventive and therapeutic roles of phytoestrogen α-Zearalanol on osteoporetic rats due to ovariectomization
(Mashhad University of Medical Sciences, 2016-11-01)Objective(s): The aim of this study was to observe the influence of phytoestrogen α-Zearalanol on ovariectomy-induced postmenopausal osteoporosis in rats. Materials and Methods ...
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Movento influences development of granulosa cells and ovarian follicles and FoxO1 and Vnn1 gene expression in BALB/c mice
(Mashhad University of Medical Sciences, 2016-11-01)Objective(s): Pesticides has wide range of infertility in female reproductive. This study was done to evaluate the effect of movento pesticide on development of granulosa cells and ovarian follicles ...
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Antifungal activity of Zataria multiflora essential oil-loaded solid lipid nanoparticles in-vitro condition
(Mashhad University of Medical Sciences, 2016-11-01)Objective(s): The aim of the present study was to prepare, characterize, and evaluate solid lipid nanoparticles (SLNs) containing Zataria multiflora essential oil (ZEO). ...
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Minocycline attenuates cirrhotic cardiomyopathy and portal hypertension in a rat model: Possible involvement of nitric oxide pathway
(Mashhad University of Medical Sciences, 2016-11-01)Objective(s): An increase in nitric oxide (NO) production has been reported in cirrhotic cardiomyopathy and, portal hypertension. Since minocycline has been shown to inhibit NO ...
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Involvement of microRNA-133 and -29 in cardiac disturbances in diabetic ovariectomized rats
(Mashhad University of Medical Sciences, 2016-11-01)Objective(s): Menopause and diabetes obviously increase the risk of cardiovascular disease in women. The aims of the present study were to evaluate the effects of ovariectomy in type 2 diabetes ...
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Effect of creatine supplementation on cognitive performance and apoptosis in a rat model of amyloid-beta-induced Alzheimer's disease
(Mashhad University of Medical Sciences, 2016-11-01)Objective(s): Neuroprotective effect of creatine (Cr) against β-amyloid (Aβ) is reported in an in vitro study. This study investigated the effect of Cr supplementation on β-amyloid toxicity ...
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The hedgehog/Gli-1 signaling pathways is involved in the inhibitory effect of resveratrol on human colorectal cancer HCT116 cells
(Mashhad University of Medical Sciences, 2016-11-01)Objective(s): The study aimed to investigate the effects of resveratrol on colorectal cancer HCT116 cells, including cell viability, apoptosis, and migration, and the partial mechanisms focused ...
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Ecstasy (MDMA) and its effects on kidneys and their treatment: a review
(Mashhad University of Medical Sciences, 2016-11-01)Ecstasy (MDMA; 3,4-methylenedioxymethylamphetamine) is an illicit drug that has been increasingly abused by young people. Its effects include euphoria, enhanced sociability and heightened mental awareness. These come about ...
