Volume 21, Issue 11
مرور بر اساس
ارسال های اخیر
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CircRNA_0109291 regulates cell growth and migration in oral squamous cell carcinoma and its clinical significance
(Mashhad University of Medical Sciences, 2018-11-01)Objective(s): Circular RNAs (circRNAs), a new class of non-coding RNAs, have emerged as important regulators during tumorigenesis. However, the functions of circRNAs have not been completely ...
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<i>Paeoniflorin</i> has anti-inflammation and neurogenesis functions through nicotinic acetylcholine receptors in cerebral ischemia-reperfusion injury rats
(Mashhad University of Medical Sciences, 2018-11-01)Objective(s): Paeoniflorin (PF) has anti-oxidation, anti-inflammation, anti-apoptosis, and neuroprotection pharmacological effects against ischemic injury. The aim of the present study was to ...
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The effects of crocetin, extracted from saffron, in chemotherapy against the incidence of multiple drug resistance phenotype
(Mashhad University of Medical Sciences, 2018-11-01)Objective(s): Crocetin, one of the main substances of saffron extract, has anti-cancer effects. Drug resistance proteins (e.g. MRP1 and MRP2) are important reasons for the failure of cancer therapy. ...
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Interaction of aquaporin 4 and N-methyl-D-aspartate NMDA receptor 1 in traumatic brain injury of rats
(Mashhad University of Medical Sciences, 2018-11-01)Objective(s): -methyl-D-aspartate NMDA receptor (NMDAR) and aquaporin 4 (AQP4) are involved in the molecular cascade of edema after traumatic brain injury (TBI) and are potential targets of studies ...
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Generation of motor neurons from human amygdala-derived neural stem-like cells
(Mashhad University of Medical Sciences, 2018-11-01)Objective(s): Among several cell sources, adult human neural stem/progenitor cells (hNS/PCs) have been considered outstanding cells for performing mechanistic studies in in vitro and in vivo models ...
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Silencing of rhomboid domain containing 1 to inhibit the metastasis of human breast cancer cells <i>in vitro</i>
(Mashhad University of Medical Sciences, 2018-11-01)Objective(s): A growing body of evidence indicates that rhomboid domain containing 1 (RHBDD1) plays an important role in a variety of physiological and pathological processes, including tumorigenesis. ...
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Combination of metformin and phenformin synergistically inhibits proliferation and hTERT expression in human breast cancer cells
(Mashhad University of Medical Sciences, 2018-11-01)Objective(s): Breast cancer remains a global challenge, and further chemopreventive therapies are still immediately required. Emerging evidence has revealed the potent anti-cancer effects of ...
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Serum-based metabolic alterations in patients with papillary thyroid carcinoma unveiled by non-targeted 1H-NMR metabolomics approach
(Mashhad University of Medical Sciences, 2018-11-01)Objective(s): As the most prevalent endocrine system malignancy, papillary thyroid carcinoma had a very fast rising incidence in recent years for unknown reasons besides the fact that the current ...
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The application of titanium dioxide (TiO2) nanoparticles in the photo-thermal therapy of melanoma cancer model
(Mashhad University of Medical Sciences, 2018-11-01)Objective(s): Photo-thermal therapy (PTT) is a therapeutic method in which photon energy is converted into heat to induce hyperthermia in malignant tumor cells. In this method, energy conversion ...
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The effects of bortezomib on the ovariectomy applied rat uterus: A histopathological, stereological and immunohistochemical study
(Mashhad University of Medical Sciences, 2018-11-01)Objective(s): In this study, potential protective effects of Bortezomib (Bort), as a proteasome inhibitor, were investigated on the uterus of ovariectomized rats by histological, morphometric and ...
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Immunohistochemical characterization of pancreatic duodenal homeobox protein-1, neurogenin-3 and insulin protein expressions in islet-mesenchymal cell <i>in vitro</i> interactions from injured adult pancreatic tissues: a morphochronological evaluation
(Mashhad University of Medical Sciences, 2018-11-01)Objective(s): The use of a co-culture of islets with mesenchymal stromal cells (MSCs) is a promising therapy in islet transplantation to revert hyperglycaemia, but the resulting insulin-producing ...
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Saffron (Crocus sativus) petal as a new pharmacological target: a review
(Mashhad University of Medical Sciences, 2018-11-01)Saffron petal is the main by-product of saffron processing which produced at high level but it is not applied and thrown out. Saffron petal is containing of several compounds such as mineral agents, anthocyanins, flavonoids, ...
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Formation of therapeutic phage cocktail and endolysin to highly multi-drug resistant <i> Acinetobacter baumannii</i>: <i> in vitro</i> and <i> in vivo</i> study
(Mashhad University of Medical Sciences, 2018-11-01)Objective(s): Phage therapy is a potential alternative treatment for infections caused by Acinetobacter baumannii, a significant nosocomial pathogen, which has evolved resistance to almost all ...
