Volume 21, Issue 10
مرور بر اساس
ارسال های اخیر
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<i>Momordica cymbalaria</i> fruit extract attenuates high-fat diet-induced obesity and diabetes in C57BL/6 mice
(Mashhad University of Medical Sciences, 2018-10-01)Objective(s): The present study was aimed to evaluate the effect of methanolic fruit extract of Momordica cymbalaria (MeMC) against high-fat diet-induced obesity and diabetes in C57BL/7 mice.
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Study of class 1 integrons in multidrug-resistant uropathogenic <i>Escherichia coli</i> isolated from different hospitals in Karachi
(Mashhad University of Medical Sciences, 2018-10-01)Objective(s): Escherichia coli is the key pathogen in the family producing ESBL (extended spectrum β-lactamase) and associated with community-acquired infections. Therefore, this study was planned ...
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Neuroprotective effects of gallic acid in a rat model of traumatic brain injury: behavioral, electrophysiological and molecular studies
(Mashhad University of Medical Sciences, 2018-10-01)Objective(s): Traumatic brain injury (TBI) is one of the main causes of intellectual and cognitive disabilities. Clinically, it is essential to limit the development of cognitive impairment after ...
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Effects of lipopolysaccharide-induced septic shock on rat isolated kidney, possible role of nitric oxide and protein kinase C pathways
(Mashhad University of Medical Sciences, 2018-10-01)Objective(s): Pathophysiology of sepsis-associated renal failure (one of the most common cause of death in intensive care units) had not been fully determined. The effect of nitric oxide and protein ...
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Biological alterations in renal and hepatic tissues by a novel gold (III) anti-cancerous compound
(Mashhad University of Medical Sciences, 2018-10-01)Objective(s): Newer organo-metallic, specifically gold (III) complexes with multiple ligands are currently being formulated with primary focus of having increased anti-cancerous properties and ...
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Pioglitazone alleviates oxygen and glucose deprivation-induced injury by up-regulation of miR-454 in H9c2 cells
(Mashhad University of Medical Sciences, 2018-10-01)Objective(s): Pioglitazone, an anti-diabetic agent, has been widely used to treat type II diabetes. However, the effect of pioglitazone on myocardial ischemia reperfusion injury (MIRI) is still ...
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Differential change in cortical and hippocampal monoamines, and behavioral patterns in streptozotocin-induced type 1 diabetes rats
(Mashhad University of Medical Sciences, 2018-10-01)Objective(s): Diabetes mellitus (DM) is a widespread metabolic disorder worldwide. Clinical physicians have found diabetic patients have mild to middle cognitive dysfunction and an alteration of ...
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Effects of insulin-loaded chitosan-alginate nanoparticle on RAGE expression and oxidative stress status in the kidney tissue of rats with type 1 diabetes
(Mashhad University of Medical Sciences, 2018-10-01)Objective(s): Chronic hyperglycemia leads to activation of the advanced glycation end products (AGE)-receptor (RAGE) for AGE axis and oxidative stress, which promote diabetic renal damage. This ...
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Adiponectin alleviate blood hypercoagulability via inhibiting endothelial cell apoptosis induced by oxidative stress in septic rats
(Mashhad University of Medical Sciences, 2018-10-01)Objective(s): The purpose of this study was to detect the protective effects of adiponectin on coagulation dysfunction and its mechanism in sepsis of rats.Materials and ...
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Evaluation of antibiotic activity of methicillin in healing of full-thickness infected wounds with sensitized methicillin resistant <i>Staphylococcus aureus</i> in presence of HAMLET
(Mashhad University of Medical Sciences, 2018-10-01)Objective(s): The novel healing choices for handling of infections due to multidrug resistant Staphylococcus aureus are reguired. HAMLET has been reported to be able to sensitize bacterial pathogens ...
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Effect of dehydroepiandrosterone on meiotic spindle structure and oocyte quality in mice
(Mashhad University of Medical Sciences, 2018-10-01)Objective(s): Dehydroepiandrosterone (DHEA) has been reported to improve pregnancy chances in women with diminished ovarian reserve (DOR) and to reduce miscarriage rates by 50–80%. This study, ...
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Medicinal plants for gingivitis: a review of clinical trials
(Mashhad University of Medical Sciences, 2018-10-01)Objective(s): Periodontal diseases are among prevalent oral health problems which may ultimately lead to severe complications in oral cavity. Herbal products can be designed as single or multicomponent ...
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Kalirin-7 plays the neuroprotective role in Neuro-2A cells injured by oxygen-glucose deprivation and reperfusion through Rac1 activation
(Mashhad University of Medical Sciences, 2018-10-01)Objective(s): The study explored the neuroprotective role of Kalirin-7 (Kal-7) in Neuro-2A cells after oxygen-glucose deprivation and reperfusion (OGD/R) treatment.Materials and ...
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Bone marrow-derived mesenchymal stem cell and simvastatin treatment leads to improved functional recovery and modified c-Fos expression levels in the brain following ischemic stroke
(Mashhad University of Medical Sciences, 2018-10-01)Objective(s): The beneficial outcomes of bone marrow-derived mesenchymal stem cell (BMSC) treatment on functional recovery following stroke has been well established. Furthermore, 5-hydroxy-3-me ...
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Sulfur dioxide reduces hippocampal cells death and improves learning and memory deficits in rat model of transient global ischemia/reperfusion
(Mashhad University of Medical Sciences, 2018-10-01)Objective(s): According to recent the findings, sulfur dioxide (SO2) is produced by the cardiovascular system, influencing some major biological processes. Based on previous research, SO2 exhibits ...
