Volume 18, Issue 10
مرور بر اساس
ارسال های اخیر
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Oxidative stress, biochemical alterations, and hyperlipidemia in female rats induced by lead chronic toxicity during puberty and post puberty periods
(Mashhad University of Medical Sciences, 2015-10-01)Objective(s):Lead (Pb) is a toxic metal inducing many destructive effects leading to a broad range of physiological, biochemical, and neurological dysfunctions in humans and laboratory animals. Materials and ...
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The effects of dried root aqueous extract of Salvia miltiorrhiza and its major ingredient in acceleration of orthodontic tooth movement in rat
(Mashhad University of Medical Sciences, 2015-10-01)Objective(s): Salvia miltiorrhiza (SM) is a popular and classic herb in traditional Chineses medicines. The objective is to confirm the effects of aqueous extract of S. miltiorrhiza (ESM) and its ...
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MiR-493 suppresses the proliferation and invasion of gastric cancer cells by targeting RhoC
(Mashhad University of Medical Sciences, 2015-10-01)Objective(s):MiRNAs have been proposed to be key regulators of tumorigenesis, progression and metastasis. However, their effect and prognostic value in gastric cancer is still poorly known. Materials ...
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Echinoderm microtubule-associated protein -like protein 5 in anterior temporal neocortex of patients with intractable epilepsy
(Mashhad University of Medical Sciences, 2015-10-01)Objective(s):EMAP-like Protein 5 (EML5) is a new echinoderm microtubule-associated protein that is expressed in the central nervous system. The aim of this study was to investigate the expression profile of EML5 ...
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Auraptene consolidates memory, reverses scopolamine-disrupted memory in passive avoidance task, and ameliorates retention deficits in mice
(Mashhad University of Medical Sciences, 2015-10-01)Objective(s): Auraptene (7-geranyloxycoumarin) (AUR), from Citrus species has shown anti-inflammatory, neuroprotective, and acetylcholinesterase (AChE) and beta-secretase inhibitory effects. Scopolamine is a ...
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The inhibitory effect of a Lactobacillus acidophilus derived biosurfactant on Serratia marcescens biofilm formation
(Mashhad University of Medical Sciences, 2015-10-01)Objective(s):Serratia marcescens is one of the nosocomial pathogen. The ability to form biofilm is an important feature in the pathogenesis of S. marcescens. The aim of this study was to determine ...
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MicroRNA-205 inhibits renal cells apoptosis via targeting CMTM4
(Mashhad University of Medical Sciences, 2015-10-01)Objective(s):MicroRNAs (miRNAs) are small non-coding RNA molecules that regulate gene expression. They have important roles in kidney development, homeostasis and disease, and participate in the onset and progression ...
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CuO nanoparticles induce cytotoxicity and apoptosis in human K562 cancer cell line via mitochondrial pathway, through reactive oxygen species and P53
(Mashhad University of Medical Sciences, 2015-10-01)Objective(s): This study focused on determining cytotoxic effects of copper oxide nanoparticles (CuO NPs) on chronic myeloid leukemia (CML) K562 cell line in a cell-specific manner and its possible mechanism of cell death. ...
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Involvement of brain-derived neurotrophic factor (BDNF) on malathion induced depressive-like behavior in subacute exposure and protective effects of crocin
(Mashhad University of Medical Sciences, 2015-10-01)Objective(s): In this study the effect of crocin, a carotenoid isolated from saffron, on malathion (an organophosphate insecticide) induced depressive- like behavior in subacute exposure was investigated. Moreover ...
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Aloe vera toxic effects: expression of inducible nitric oxide synthase (iNOS) in testis of Wistar rat
(Mashhad University of Medical Sciences, 2015-10-01)Objective(s): Nitric oxide (NO), a product of inducible nitric oxide synthase (iNOS), contributes in germ cell apoptosis. This study was aimed to evaluate the effects of Aloe vera gel (AVG) on male Wistar ...
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Nitric oxide in the nucleus raphe magnus modulates cutaneous blood flow in rats during hypothermia
(Mashhad University of Medical Sciences, 2015-10-01)Objective(s): Nucleus Raphe Magnus (NRM) that is involved in the regulation of body temperature contains nitric oxide (NO) synthase. Considering the effect of NO on skin blood flow control, in this study, we ...
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Betaine protects cerebellum from oxidative stress following levodopa and benserazide administration in rats
(Mashhad University of Medical Sciences, 2015-10-01)Objective(s): The aim of the present study was to evaluate antioxidant and methyl donor effects of betaine in cerebellum following levodopa and benserazide administration in rats. Materials and Methods: ...
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Determination of valproic acid in human plasma using dispersive liquid-liquid microextraction followed by gas chromatography-flame ionization detection
(Mashhad University of Medical Sciences, 2015-10-01)Objective(s): Dispersive liquid-liquid microextraction coupled with gas chromatography (GC)-flame ionization detector was developed for the determination of valproic acid (VPA) in human plasma. Materials and Methods: Using ...
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The vasodilatory action of telmisartan on isolated mesenteric artery rings from rats
(Mashhad University of Medical Sciences, 2015-10-01)Objective(s): Angiotensin Ⅱ type 1 receptor blockers (ARBs) represent one of the widely used antihypertensive agents. In addition to anti-hypertension effect, some ARBs also show other molecular effects such as ...
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Structural characterization of rat ventricular tissue exposed to the smoke of two types of waterpipe
(Mashhad University of Medical Sciences, 2015-10-01)Objective(s):this study focused on the effect of waterpipe smoke exposure toxicity on the structure of albino rat's ventricular tissue and their recovery. Materials and Methods: Albino rats were ...
