Volume 20, Issue 6
مرور بر اساس
ارسال های اخیر
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Design of peptides interfering with iron-dependent regulator (IdeR) and evaluation of Mycobacterium tuberculosis growth inhibition
(Mashhad University of Medical Sciences, 2017-06-01)Objective(s): Tuberculosis (TB), a disease caused by Mycobacterium tuberculosis (Mtb), stayed a global health thread with high mortality rate. Since TB has a long-term treatment, ...
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Allicin attenuates tunicamycin-induced cognitive deficits in rats via its synaptic plasticity regulatory activity
(Mashhad University of Medical Sciences, 2017-06-01)Objective(s): To illuminate the functional effects of allicin on rats with cognitive deficits induced by tunicamycin (TM) and the molecular mechanism of this process. Materials ...
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Orthotopic liver transplantation from cardiac death donors in the mouse: a new model and evaluation of cardiac death time
(Mashhad University of Medical Sciences, 2017-06-01)Objective(s): The goal of this research was to develop a mouse orthotopic liver transplantation (LTx) model from donor-after-cardiac-death (DCD) grafts. Materials and Methods: ...
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Restoration of correct splicing in IVSI-110 mutation of β-globin gene with antisense oligonucleotides: implications and applications in functional assay development
(Mashhad University of Medical Sciences, 2017-06-01)Objective(s): The use of antisense oligonucleotides (AOs) to restore normal splicing by blocking the recognition of aberrant splice sites by the spliceosome represents an innovative means of ...
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Melatonin upregulates ErbB1 and ErbB4, two primary implantation receptors, in pre-implantation mouse embryos
(Mashhad University of Medical Sciences, 2017-06-01)Objective(s): To evaluated the effects of melatonin on early embryo competence and the expression rate of the primary implantation receptors (ErbB1 and ErbB4). Materials and ...
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Novel cilostamide analogs, phosphodiesterase 3 inhibitors, produce positive inotropic but differential lusitropic and chronotropic effects on isolated rat atria
(Mashhad University of Medical Sciences, 2017-06-01)Objective(s): Recently, we showed that some new synthetic compounds structurally related to cilostamide (4-(1,2-dihydro-2-oxoquinolin-6-hydroxy)- N-cyclohexyl-N-methylbutanamide), a selective ...
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Coumarin derivatives bearing benzoheterocycle moiety: synthesis, cholinesterase inhibitory, and docking simulation study
(Mashhad University of Medical Sciences, 2017-06-01)Objective(s): To investigate the efficiency of a novel series of coumarin derivatives bearing benzoheterocycle moiety as novel cholinesterase inhibitors. Materials and ...
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Effects of left prefrontal transcranial direct current stimulation on the acquisition of contextual and cued fear memory
(Mashhad University of Medical Sciences, 2017-06-01)Objective(s): Behavioral and neuroimaging studies have shown that transcranial direct current stimulation, as a non-invasive neuromodulatory technique, beyond regional effects can modify functionally ...
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Establishment of human hair follicle mesenchymal stem cells with overexpressed human hepatocyte growth factor
(Mashhad University of Medical Sciences, 2017-06-01)Objective(s): Chronic liver disease has become a major health problem that causes serious damage to human health. Since the existing treatment effect was not ideal, we need to seek new treatment ...
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Cxcr4 expression is associated with time–course permanent and temporary myocardial infarction in rats
(Mashhad University of Medical Sciences, 2017-06-01)Objective(s): Experimental myocardial infarction triggers secretion of Stromal cell-derived factor1 and lead to increase in the expression of its receptor "CXCR4" on the surface of various cells. ...
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Bio-effectiveness of the main flavonoids of Achillea millefolium in the pathophysiology of neurodegenerative disorders- a review
(Mashhad University of Medical Sciences, 2017-06-01)The Achillea millefolium L. (Yarrow) is a common herb which is widely being used, worldwide. Achillea is being used for treatment of many disorders since centuries. It is considered safe for supplemental ...
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Thiadiazoles: the appropriate pharmacological scaffolds with leishmanicidal and antimalarial activities: a review
(Mashhad University of Medical Sciences, 2017-06-01)Leishmaniasis and malaria are serious public health problems in tropical and sub-tropical regions worldwide. Development of drug-resistant strains has disrupted efforts to control the spread of these diseases in the world. ...
