Volume 20, Issue 5
مرور بر اساس
ارسال های اخیر
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The effects of ethanol extract of Berberis vulgaris fruit on histopathological changes and biochemical markers of the liver damage in diabetic rats
(Mashhad University of Medical Sciences, 2017-05-01)Objective(s): Various studies have shown that the diabetes is associated with liver failure. The objective of this study was determining the effects of Berberis vulgaris fruit on ...
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A review of the effects of Berberis vulgaris and its major component, berberine, in metabolic syndrome
(Mashhad University of Medical Sciences, 2017-05-01)Metabolic syndrome (MetS), characterized by a cluster of metabolic abnormalities including hypertension, obesity, type 2 diabetes mellitus (T2DM) and dyslipidemia, is a well-known cardiovascular risk factor (CVRF). ...
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Berberine protects against glutamate-induced oxidative stress and apoptosis in PC12 and N2a cells
(Mashhad University of Medical Sciences, 2017-05-01)Objective(s): Neurodegenerative diseases have been associated with glutamatergic dysfunction. Berberine, an isoquinoline alkaloid broadly present in different medicinal herbs, has been reported ...
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Berberine protects against metformin-associated lactic acidosis in induced diabetes mellitus
(Mashhad University of Medical Sciences, 2017-05-01)Objective(s): Causality of occurrence of metformin-associated lactic acidosis (MALA) is a clinical problem. Currently, there is no drug available to prevent MALA. The present study was conducted ...
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Toxicology effects of Berberis vulgaris (barberry) and its active constituent, berberine: a review
(Mashhad University of Medical Sciences, 2017-05-01)Berberis vulgaris and berberine, its main component, traditionally have been used for treatment of various disorders. The pharmacological properties of them have been investigated using different in vivo ...
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MiR-570 inhibits cell proliferation and glucose metabolism by targeting IRS1 and IRS2 in human chronic myelogenous leukemia
(Mashhad University of Medical Sciences, 2017-05-01)Objective(s): Chronic myelogenous leukemia (CML) is a chronic myeloproliferative disorder characterized by the accumulation of myeloid cells with a chromosomal translocation known as the Philadelphia ...
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In vivo immunotherapy of lung cancer using cross-species reactive vascular endothelial growth factor nanobodies
(Mashhad University of Medical Sciences, 2017-05-01)Objective(s): Lung cancer is the main leading cause of cancer death worldwide. Angiogenesis is the main step in proliferation and spreading of tumor cells. Targeting vascular endothelial growth ...
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Synergism effects of pioglitazone and Urtica dioica extract in streptozotocin-induced nephropathy via attenuation of oxidative stress
(Mashhad University of Medical Sciences, 2017-05-01)Objective(s): Hyperglycemia promotes oxidative stress that plays a crucial role in the pathogenesis of Diabetic nephropathy (DN). In this study, we investigated the synergism effects of hydroalcoholic ...
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Construction, expression, purification and characterization of secretin domain of PilQ and triple PilA-related disulfide loop peptides fusion protein from Pseudomonas aeruginosa
(Mashhad University of Medical Sciences, 2017-05-01)Objective(s): Infection with Pseudomonas aeruginosa has been a long-standing obstacle for clinical therapy due to the complexity of the genetics and pathogenesis, as well for widespread ...
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Commentary: Comparison of activated charcoal and sodium polystyrene sulfonate resin efficiency on reduction of amitriptyline oral absorption in rat as treatments for overdose and toxicities
(Mashhad University of Medical Sciences, 2017-05-01)
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One-step purification and characterization of alginate lyase from a clinical Pseudomonas aeruginosa with destructive activity on bacterial biofilm
(Mashhad University of Medical Sciences, 2017-05-01)Objective(s): Pseudomonas aeruginosais a Gram-negative and aerobic rod bacterium that displays mucoid and non-mucoid phenotype. Mucoid strains secrete alginate, which is the main agent ...
