Volume 23, Issue 4
مرور بر اساس
ارسال های اخیر
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Analysis of the active fraction of Iranian Naja naja oxiana snake venom on the metabolite profiles of the malaria parasite by 1HNMR <i>in vitro</i>
(Mashhad University of Medical Sciences, 2020-04-01)Objective(s): Malaria is an important parasitic disease with high morbidity and mortality in tropical areas. Resistance to most antimalarial drugs has encouraged the development of new drugs ...
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Differential gene expression by lithium chloride induction of adipose-derived stem cells into neural phenotype cells
(Mashhad University of Medical Sciences, 2020-04-01)Objective(s): Adipose-derived stem cells (ADSCs), with suitable and easy access, are multipotential cells that have the ability for differentiation into other mesodermal and transdifferentiate ...
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Induction of humoral immune responses and inhibition of metastasis in mice by a VEGF peptide-based vaccine
(Mashhad University of Medical Sciences, 2020-04-01)Objective(s): Blocking of vascular endothelial growth factor (VEGF) plays a pivotal role in inhibition of metastasis and is a target for development of anti-angiogenic agents. In this study, a ...
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Hydrogen-rich saline ameliorates hippocampal neuron apoptosis through up-regulating the expression of cystathionine β-synthase (CBS) after cerebral ischemia- reperfusion in rats
(Mashhad University of Medical Sciences, 2020-04-01)Objective(s): This study aimed to evaluate the potential role of hydrogen in rats after cerebral ischemic/reperfusion (I/R) injury. Materials and Methods: The ...
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Apoptosis induction and proliferation inhibition by silibinin encapsulated in nanoparticles in MIA PaCa-2 cancer cells and deregulation of some miRNAs
(Mashhad University of Medical Sciences, 2020-04-01)Objective(s): Silibinin, as an herbal compound, has anti-cancer activity. Because of low solubility of silibinin in water and body fluids, it was encapsulated in polymersome nanoparticles and its ...
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High proviral load of human T cell lymphotropic virus type-1 facilitates coronary artery diseases
(Mashhad University of Medical Sciences, 2020-04-01)Objective(s): Coronary artery disease (CAD) is known as a life threatening disease, worldwide. In this study the role of HTLV-1 infection was evaluated on cardiac involvement in an endemic region ...
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Effect of treadmill exercise on catalepsy and the expression of the BDNF gene in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine male <i>NMRI</i> mice
(Mashhad University of Medical Sciences, 2020-04-01)Objective(s): It is known that treadmill exercise has beneficial effects on the nervous system. The brain-derived neurotrophic factor (BDNF) plays a role in such effects. This study aimed at ...
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PuraMatrix hydrogel enhances the expression of motor neuron progenitor marker and improves adhesion and proliferation of motor neuron-like cells
(Mashhad University of Medical Sciences, 2020-04-01)Objective(s): Cell therapy has provided clinical applications to the treatment of motor neuron diseases. The current obstacle in stem cell therapy is to direct differentiation of stem cells into ...
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PHA stimulation may be useful for FDXR gene expression-based biodosimetry
(Mashhad University of Medical Sciences, 2020-04-01)Objective(s): Nowadays, ionizing radiation (IR) has a significant contribution to the diagnostic and therapeutic medicine, and following that, health risks to individuals through unexpected exposure ...
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Biochemical and computational study of an alginate lyase produced by <i>Pseudomonas aeruginosa</i> strain S21
(Mashhad University of Medical Sciences, 2020-04-01)Objective(s): Alginates play a key role in mucoid Pseudomonas aeruginosa colonization, biofilm formation, and driving out of cationic antibiotics. P. aeruginosa alginate lyase (AlgL) is a periplasmic ...
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Monascin ameliorate inflammation in the lipopolysaccharide-induced BV-2 microglial cells via suppressing the NF-κB/p65 pathway
(Mashhad University of Medical Sciences, 2020-04-01)Objective(s): The pathophysiology of neurodegenerative diseases is complicated, in which inflammatory reactions play a vital role. Microglia cells activation, an essential process of neuroinflammation, ...
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Efficacy of insulin targeted gene therapy for type 1 diabetes mellitus: A systematic review and meta-analysis of rodent studies
(Mashhad University of Medical Sciences, 2020-04-01)Objective(s): Diabetes mellitus (DM) is a major worldwide public health challenge, for which gene therapy offers a potential therapeutic approach. To date, no systematic review or meta-analysis ...
