Volume 19, Issue 4
مرور بر اساس
ارسال های اخیر
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Evaluation of antioxidant and cytoprotective activities of Artemisia ciniformis extracts on PC12 cells
(Mashhad University of Medical Sciences, 2016-04-01)Objective(s): In the current study antioxidant capacities of five different extracts of Artemisia ciniformis aerial parts were evaluated by cell-free methods. Then seven fractions of the ...
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Design of cocktail peptide vaccine against Cytomegalovirus infection
(Mashhad University of Medical Sciences, 2016-04-01)Objective(s):Human Cytomegalovirus (HCMV) remains a major morbidity and mortality cause in immuno suppressed patients. Therefore, significant effort has been made towards the development ...
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Brain-derived neurotrophic and immunologic factors: beneficial effects of riboflavin on motor disability in murine model of multiple sclerosis
(Mashhad University of Medical Sciences, 2016-04-01)Objective(s): In the present study, C57BL/6 female mice (n=56) were used to explore the neuroprotective effects of riboflavin in motor disability of experimental autoimmune encephalomyelitis (EAE) ...
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Naringin ameliorates cognitive deficits in streptozotocin-induced diabetic rats
(Mashhad University of Medical Sciences, 2016-04-01)Objective(s):Previous research demonstrated that diabetes is one of the leading causes of learning and memory deficits. Naringin, a bioflavonoid isolated from grapefruits and oranges, has potent ...
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The effect of spinally administered WIN 55,212-2, a cannabinoid agonist, on thermal pain sensitivity in diabetic rats
(Mashhad University of Medical Sciences, 2016-04-01)Objective(s):Diabetic neuropathy (DN) is a common complication of diabetes that leads to allodynia, impaired nerve conduction, and progressive sensory loss. The aim of this study was to observe ...
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Effect of carvacrol on various cytokines genes expression in splenocytes of asthmatic mice
(Mashhad University of Medical Sciences, 2016-04-01)Objective(s):With regard to pharmacological effects of carvacrol on the respiratory system, its effect on cytokines genes expression in splenocytes of asthmatic mice was examined in this ...
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Inhibitory effect of clemastine on P-glycoprotein expression and function: an in vitro and in situ study
(Mashhad University of Medical Sciences, 2016-04-01)Objective(s):Transporters have an important role in pharmacokinetics of drugs. Inhibition or induction of drug transporters activity can affect drug absorption, safety, and efficacy. P-glycoprotein ...
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Quinazoline derivative compound (11d) as a novel angiogenesis inhibitor inhibiting VEGFR2 and blocking VEGFR2-mediated Akt/mTOR /p70s6k signaling pathway
(Mashhad University of Medical Sciences, 2016-04-01)Objective(s): We previously reported a series of quinazoline derivatives as vascular-targeting anticancer agents. In this study, we investigated the mechanism underlying the anti-angiogenic activity ...
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Parental cigarette smoking, transforming growth factor-alpha gene variant and the risk of orofacial cleft in Iranian infants
(Mashhad University of Medical Sciences, 2016-04-01)Objective(s):We investigated the influence of genetic variation of the transforming growth-factor alpha (TGFA) locus on the relationship between smoking and oral clefts.
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Effects of 1,25-dihydroxyvitamin D3 on IL-17/IL-23 axis, IFN-γ and IL-4 expression in systemic lupus erythematosus induced mice model
(Mashhad University of Medical Sciences, 2016-04-01)Objective(s): Systemic lupus erythematosus (SLE) is a multi-factorial autoimmune disease which may be characterized by T lymphocytes dysfunctions. Th17 cells have been identified as new effector ...
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Expression of the Mir-133 and Bcl-2 could be affected by swimming training in the heart of ovariectomized rats
(Mashhad University of Medical Sciences, 2016-04-01)Objective(s): The beneficial and more potent role of exercise to prevent heart apoptosis in ovariectomized rats has been known. The aim of this study was to examine the effects of swimming training ...
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Assessment of oxidative stress parameters of brain-derived neurotrophic factor heterozygous mice in acute stress model
(Mashhad University of Medical Sciences, 2016-04-01)Objective(s): Exposing to stress may be associated with increased production of reactive oxygen species (ROS). Therefore, high level of oxidative stress may eventually give rise to accumulation ...
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Apoptosis inducing capacity of Holothuria arenicola in CT26 colon carcinoma cells in vitro and in vivo
(Mashhad University of Medical Sciences, 2016-04-01)Objective(s):Sea cucumber is one of the classes of echinoderms, which is considered as a health marine product and possess various biological characteristics with therapeutic application. The ...
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Tracheal overexpression of IL-1β, IRAK-1 and TRAF-6 mRNA in obese-asthmatic male Wistar rats
(Mashhad University of Medical Sciences, 2016-04-01)Objective(s): Human and animal studies have shown a close relationship between obesity and asthma severity. Here, we examined the effects of diet-induced obesity (DIO) on the expression levels of ...
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Nonsense-mediated mRNA decay among coagulation factor genes
(Mashhad University of Medical Sciences, 2016-04-01)Objective(s): Haemostasis prevents blood loss following vascular injury. It depends on the unique concert of events involving platelets and specific blood proteins, known as coagulation factors. ...



