Volume 19, Issue 4
مرور بر اساس
ارسال های اخیر
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Evaluation of antioxidant and cytoprotective activities of Artemisia ciniformis extracts on PC12 cells
(Mashhad University of Medical Sciences, 2016-04-01)Objective(s): In the current study antioxidant capacities of five different extracts of Artemisia ciniformis aerial parts were evaluated by cell-free methods. Then seven fractions of the ...
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Design of cocktail peptide vaccine against Cytomegalovirus infection
(Mashhad University of Medical Sciences, 2016-04-01)Objective(s):Human Cytomegalovirus (HCMV) remains a major morbidity and mortality cause in immuno suppressed patients. Therefore, significant effort has been made towards the development ...
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Brain-derived neurotrophic and immunologic factors: beneficial effects of riboflavin on motor disability in murine model of multiple sclerosis
(Mashhad University of Medical Sciences, 2016-04-01)Objective(s): In the present study, C57BL/6 female mice (n=56) were used to explore the neuroprotective effects of riboflavin in motor disability of experimental autoimmune encephalomyelitis (EAE) ...
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The effect of spinally administered WIN 55,212-2, a cannabinoid agonist, on thermal pain sensitivity in diabetic rats
(Mashhad University of Medical Sciences, 2016-04-01)Objective(s):Diabetic neuropathy (DN) is a common complication of diabetes that leads to allodynia, impaired nerve conduction, and progressive sensory loss. The aim of this study was to observe ...
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Effect of carvacrol on various cytokines genes expression in splenocytes of asthmatic mice
(Mashhad University of Medical Sciences, 2016-04-01)Objective(s):With regard to pharmacological effects of carvacrol on the respiratory system, its effect on cytokines genes expression in splenocytes of asthmatic mice was examined in this ...
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Quinazoline derivative compound (11d) as a novel angiogenesis inhibitor inhibiting VEGFR2 and blocking VEGFR2-mediated Akt/mTOR /p70s6k signaling pathway
(Mashhad University of Medical Sciences, 2016-04-01)Objective(s): We previously reported a series of quinazoline derivatives as vascular-targeting anticancer agents. In this study, we investigated the mechanism underlying the anti-angiogenic activity ...
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Inhibitory effect of clemastine on P-glycoprotein expression and function: an in vitro and in situ study
(Mashhad University of Medical Sciences, 2016-04-01)Objective(s):Transporters have an important role in pharmacokinetics of drugs. Inhibition or induction of drug transporters activity can affect drug absorption, safety, and efficacy. P-glycoprotein ...
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Parental cigarette smoking, transforming growth factor-alpha gene variant and the risk of orofacial cleft in Iranian infants
(Mashhad University of Medical Sciences, 2016-04-01)Objective(s):We investigated the influence of genetic variation of the transforming growth-factor alpha (TGFA) locus on the relationship between smoking and oral clefts.
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Assessment of oxidative stress parameters of brain-derived neurotrophic factor heterozygous mice in acute stress model
(Mashhad University of Medical Sciences, 2016-04-01)Objective(s): Exposing to stress may be associated with increased production of reactive oxygen species (ROS). Therefore, high level of oxidative stress may eventually give rise to accumulation ...
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Apoptosis inducing capacity of Holothuria arenicola in CT26 colon carcinoma cells in vitro and in vivo
(Mashhad University of Medical Sciences, 2016-04-01)Objective(s):Sea cucumber is one of the classes of echinoderms, which is considered as a health marine product and possess various biological characteristics with therapeutic application. The ...
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Nonsense-mediated mRNA decay among coagulation factor genes
(Mashhad University of Medical Sciences, 2016-04-01)Objective(s): Haemostasis prevents blood loss following vascular injury. It depends on the unique concert of events involving platelets and specific blood proteins, known as coagulation factors. ...
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Tracheal overexpression of IL-1β, IRAK-1 and TRAF-6 mRNA in obese-asthmatic male Wistar rats
(Mashhad University of Medical Sciences, 2016-04-01)Objective(s): Human and animal studies have shown a close relationship between obesity and asthma severity. Here, we examined the effects of diet-induced obesity (DIO) on the expression levels of ...



