Volume 22, Issue 4
مرور بر اساس
ارسال های اخیر
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Mechanistic assessment of cadmium toxicity in association with the functions of estrogen receptors in the Langerhans islets
(Mashhad University of Medical Sciences, 2019-04-01)Objective(s): Diabetes is a metabolic disease with an increasing prevalence for which finding new and efficient therapeutic approaches has always been a challenge. Preserving integrity and ...
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Gallic acid protects the liver in rats against injuries induced by transient ischemia-reperfusion through regulating microRNAs expressions
(Mashhad University of Medical Sciences, 2019-04-01)Objective(s): Gallic acid (GA) is a highly effective antioxidant, which its beneficial effects are well known, but its impact on expression of microRNAs (miRs) following hepatic ischemia-reperfusion ...
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Comparative evaluation of NOTCH signaling molecules in the endometrium of women with various gynecological diseases during the window of implantation
(Mashhad University of Medical Sciences, 2019-04-01)Objective(s): NOTCH signaling pathway is well known for its role in cell fate, cell survival, cell differentiation, and apoptosis. Some of the NOTCH signaling genes are critical for endometrial ...
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Protective effect of lutein on spinal cord ischemia-reperfusion injury in rats
(Mashhad University of Medical Sciences, 2019-04-01)Objective(s): Paraplegia is deterioration in motor or sensory function of the lower limbs that can occur after modification of a thoracoabdominal aortic aneurysm. The purpose of this survey was ...
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Simultaneous regulation of miR-451 and miR-191 led to erythroid fate decision of mouse embryonic stem cell
(Mashhad University of Medical Sciences, 2019-04-01)Objective(s): Various microRNAs (miRNAs) are expressed during development of mammalian cells, when they aid in modulating gene expression by mediating mRNA transcript cleavage and/or regulation ...
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Investigating the anti-tumoral effect of curcumin on the mice in which Ehrlich ascites and solid tumor is created
(Mashhad University of Medical Sciences, 2019-04-01)Objective(s): In this study, the effects of different doses of curcumin application on Ehrlich ascites tumor (EAT) created in the mice of BALB/c type were investigated.Materials ...
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Empagliflozin alleviates renal inflammation and oxidative stress in streptozotocin-induced diabetic rats partly by repressing HMGB1-TLR4 receptor axis
(Mashhad University of Medical Sciences, 2019-04-01)Objective(s): Empagliflozin, a sodium-glucose cotransporter-2 (SGLT-2) inhibitor, possesses verified anti-inflammatory and anti-oxidative stress effects against diabetic nephropathy. The present ...
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Therapeutic and protective effects of montelukast against doxorubicin-induced acute kidney damage in rats
(Mashhad University of Medical Sciences, 2019-04-01)Objective(s): The current study was designed to investigate the therapeutic and protective effects of montelukast (ML) against doxorubicin (DOX)-induced acute kidney damage in rats.
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Protective effects of curcumin on diabetic nephropathy via attenuation of kidney injury molecule 1 (KIM-1) and neutrophil gelatinase-associated lipocalin (NGAL) expression and alleviation of oxidative stress in rats with type 1 diabetes
(Mashhad University of Medical Sciences, 2019-04-01)Objective(s): One of the serious complications of Type1 diabetes (T1D) is diabetic nephropathy, which is accompanied with overexpression of kidney injury molecule 1 (KIM-1) and neutrophil ...
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Nanoparticle or conventional adjuvants: which one improves immune response against Brucellosis?
(Mashhad University of Medical Sciences, 2019-04-01)Objective(s): Brucellosis is a common infectious disease among animals and humans. While subunit vaccines could be used as an efficient strategy against pathogens, they usually seem to be less ...
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Immunoregulatory and anti-inflammatory properties of <i>Crocus sativus</i> (Saffron) and its main active constituents: A review
(Mashhad University of Medical Sciences, 2019-04-01)The medicinal uses of saffron, the dried stigmas of Crocus sativus L., have very long history in food coloring agent, and flavoring agent as well as traditional medicine for the treatment of several diseases. Crocus sativus ...
