Volume 21, Issue 3
مرور بر اساس
ارسال های اخیر
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Anti-diabetic effects of Sargassum oligocystum on Streptozotocin- induced diabetic rat
(Mashhad University of Medical Sciences, 2018-03-01)Objective(s): Diabetes is a metabolic syndrome which is associated with the worldwide major public health problems. There are many natural compounds from the sea-market, as a valuable aquatic ...
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The inhibitory effects of 20(R)-ginsenoside Rg3 on the proliferation, angiogenesis and collagen synthesis of hypertrophic scar derived fibroblasts in vitro
(Mashhad University of Medical Sciences, 2018-03-01)Objective(s): Therapeutic effect of many selectable methods applied in clinical practice for treating hypertrophic scar (HS) is not still so satisfactory. Meanwhile, a few medicines may lead to ...
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The first case of NSHL by direct impression on EYA1 gene and identification of one novel mutation in MYO7A in the Iranian families
(Mashhad University of Medical Sciences, 2018-03-01)Objective(s): Targeted next-generation sequencing (NGS) provides a consequential opportunity to elucidate genetic factors in known diseases, particularly in profoundly heterogeneous disorders such ...
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MiR-103 regulates the angiogenesis of ischemic stroke rats by targeting vascular endothelial growth factor (VEGF)
(Mashhad University of Medical Sciences, 2018-03-01)Objective(s): To investigate the effect of miR-103 on the angiogenesis of ischemic stroke rats via targeting vascular endothelial growth factor (VEGF) at the molecular level. Materials ...
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Bax/Bcl-2 expression ratio in prediction of response to breast cancer radiotherapy
(Mashhad University of Medical Sciences, 2018-03-01)Objective(s): Radiotherapy is one of the most effective modalities of cancer therapy, but clinical responses of individual patients varies considerably. To enhance treatment efficiency it is ...
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Role of melatonin receptors in the effect of estrogen on brain edema, intracranial pressure and expression of aquaporin 4 after traumatic brain injury
(Mashhad University of Medical Sciences, 2018-03-01)Objective(s): Traumatic brain injury (TBI) is one of the most common causes of death and disability in modern societies. The role of steroids and melatonin is recognized as a neuroprotective factor ...
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Protective effect of scutellarin on myocardial infarction induced by isoprenaline in rats
(Mashhad University of Medical Sciences, 2018-03-01)Objective(s): Scutellarin (Scu) is the main effective constituent of Erigeron breviscapuswhich hasanti-oxidant, anti-apoptotic, anti-inflammatory and other therapeutic properties. ...
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Immunogenicity of enterotoxigenic Escherichia coli outer membrane vesicles encapsulated in chitosan nanoparticles
(Mashhad University of Medical Sciences, 2018-03-01)Objective(s): Enterotoxigenic Escherichia coli (ETEC) is an important cause of diarrheal disease in humans, particularly in children under 5 years and travelers in developing countries.
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MiR-103 alleviates autophagy and apoptosis by regulating SOX2 in LPS-injured PC12 cells and SCI rats
(Mashhad University of Medical Sciences, 2018-03-01)Objective(s): Recent studies revealed that microRNAs (miRNAs) may play crucial roles in the responses and pathologic processes of spinal cord injury (SCI). This study aimed to investigate the ...
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MiR-9-5p and miR-106a-5p dysregulated in CD4+ T-cells of multiple sclerosis patients and targeted essential factors of T helper17/regulatory T-cells differentiation
(Mashhad University of Medical Sciences, 2018-03-01)Objective(s): Multiple sclerosis (MS) is considered as a chronic type of an inflammatory disease characterized by loss of myelin of CNS.Recent evidence indicates that Interleukin 17 (IL-17)-producing ...
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Design of a humanized anti vascular endothelial growth factor nanobody and evaluation of its in vitro function
(Mashhad University of Medical Sciences, 2018-03-01)Objective(s): Nanobodies, the single domain antigen binding fragments of heavy chain-only antibodies occurring naturally in camelid sera, are the smallest intact antigen binding entities. Their ...
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Chronic intermittent hypobaric hypoxia attenuates monocrotaline-induced pulmonary arterial hypertension via modulating inflammation and suppressing NF-κB /p38 pathway
(Mashhad University of Medical Sciences, 2018-03-01)Objective(s): Inflammation is involved in various forms of pulmonary arterial hypertension (PAH). Although the pathophysiology of PAH remains uncertain, NF-κB and p38 mitogen-activated protein ...
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Amelioration of carbon tetrachloride-induced hepatic injury by emulsified Antrodia extract
(Mashhad University of Medical Sciences, 2018-03-01)Objective(s): Antrodia cinnamomea (AC) is found with anti-inflammatory and immunomodulatory biological activities. In this study, we investigated the anti-hepatitis effect of the ...
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The effect of bone marrow mesenchymal stem cells on recovery of skeletal muscle after neurotization surgery in rat
(Mashhad University of Medical Sciences, 2018-03-01)Objective(s): When the nerve is injured near its entrance to the muscle belly, we cannot perform conventional methods. One useful method in such a situation is neurotization surgery. In this study, ...
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The cucurbitacins D, E, and I from Ecballium elaterium (L.) upregulate the LC3 gene and induce cell-cycle arrest in human gastric cancer cell line AGS
(Mashhad University of Medical Sciences, 2018-03-01)Objective(s): Cucurbitacins exhibit a range of anti-cancer functions. We investigated the effects of cucurbitacins D, E, and I purified from Ecballium elaterium (L.) A. Rich fruits on ...
