Chemotherapeutic Effects of Different Paclitaxel plus Poldine Combination Methods for Treatment of Ovarian Carcinoma

Abstract

The study aimed to evaluate the curative effects and toxicity of different paclitaxel (PTX) plus poldinechemotherapeutic combination methods for treatment of advanced ovarian carcinoma. A total of 27 patients withovarian epithelial carcinoma were divided into four groups: A1, taxotere plus poldine intravenous chemotherapy(n=5); A2, taxotere intravenous chemotherapy combined with poldine intraperitoneal chemotherapy (n=7); B1,paclitaxel plus poldine intravenous chemotherapy (n=6); B2, paclitaxel intravenous chemotherapy combinedwith poldine intraperitoneal chemotherapy (n=9). Toxic side effects were observed after chemotherapy, and theshort-term effects were assessed. Some 25 (25/27) cases completed a four-course treatment, the remaining twostopping halfway due to anaphylactic shock. The total effective rate for the A1 Group was 60% (3/5) and thatof A2 group was 71.4% (5/7), Figuires for the B1 and B2 groups were 50%(3/6) and 66.7% (6/9), respectively.In comparisons of toxic side reactions, there were significant differences between taxotere groups and paclitaxelgroups, and between intravenous chemotherapy alone groups and intravenous plus intraperitoneal combinationchemotherapy groups (p<0.05). Chemotherapy of toxol plus poldine was effective in treatment of advancedovarian cancer, the toxicities of intravenous plus intraperitoneal combination chemotherapy was lower thanthat of intravenous chemotherapy alone, and the heart toxicity with taxoere was lower than with paclitexal.