Application of silica vanadic acid as a dual Lewis and Bronsted acid catalytic ability in Dakin West reaction

Abstract

Silica Vanadic Acid, SVA, (oxo-vanadium has been supported on silica) as a dual Lewis and Bronsted acid ability was prepared and efficiently catalyzed one-pot multi-component condensation of enolizable ketones or alkyl acetoacetates with aromatic aldehydes, acetonitrile and acetyl chloride. The described reaction was produced β-acetamido ketone or ester derivatives in high to excellent yields in relatively short reaction times in heterogeneous catalytic system at room temperature. Other advantages of this method is applicable at large scales without significant loss of the yields. In addition, this method is superior to reported methods, for the synthesis of β-acetamido ketone or ester derivatives.