In vitro and in vivo Evaluation of the Antitumor Efficiency ofResveratrol Against Lung Cancer

Abstract

Lung cancer remains a deadly disease with unsatisfactory overall survival. Resveratrol (Res) has the potentialto inhibit growth of several types of cancer such as prostate and colorectal examples. In the current study, weevaluated in vitro and in vivo anticancer efficiency of Res in a xenograft model with A549 cells. Cell inhibitioneffects of Res were measured by MTT assay. Apoptotis of A549 cells was assessed with reference to caspase-3activity and growth curves of tumor volume and bodyweight of the mice were measured every two days. Invitro cytotoxicity evaluation indicated Res to exert dose-dependent cell inhibition effects against A549 cells withactivation of caspase-3. In vivo evaluation showed Res to effectively inhibit the growth of lung cancer in a dosedependentmanner in nude mice. Therefore, we believe that Res might be a promising phytomedicine for cancertherapy and further efforts are needed to explore this potential therapeutic strategy.