Tissue Expression, Serum and Salivary Levels of IL-10 inPatients with Head and Neck Squamous Cell Carcinoma

Abstract

<strong>Background:</strong> Head and neck SCC is a common cancer related to various factors. IL-10, a pleiotropic cytokineproduced by macrophages, T-helper-2 cells, and B lymphocytes, is thought to play a potential pathogenetic ortherapeutic role in a number of human conditions, such as inflammation, autoimmunity and cancer. The presentstudy was designed to evaluate the relation between tissue expression, serum and salivary levels of IL-10 in headand neck squamous cell carcinomas (HNSCCs) and their correlation with clinicopathologic features. Materialsand <br /><strong>Methods</strong>: Samples were collected from 30 patients with HNSCCs and 24 healthy volunteers. IHC analysiswas used to examine the tissue expression and ELISA was employed to measure serum and salivary levels.<br /><strong>Results</strong>: Our study showed tissue expression of IL-10 to be significantily higher in patients (P: 0.001), but therewas no relation between tissue expression , serum and salivary levels of the marker (P>0.05). Also except for apositive correlation between tissue expression of IL-10 and stage (P: 0.044), there was no relation between thismarker and clinicopathologic features. There was no correlation between serum and salivary levels in eitherpatients or controls. <br /><strong>Conclusions</strong>: It seems there is no correlation between level of IL-10 in serum and salivaand this marker in saliva and serum does not reflect tissue expression.