Scoring System and Management Algorithm Assessing theRole of Survivin Expression in Predicting Progressivity of HPVInfections in Precancerous Cervical Lesions

Abstract

<strong>Background:</strong> To identify the risk factors and assess the role of survivin in predicting progessivity precancerouscervical lesions. Materials and <br /><strong>Methods</strong>: This case-control study was conducted from October 2009 until May2010. We obtained 74 samples, classified according to the degree of cervical intraepithelial neoplasia (CIN):19 samples for CIN 1, 18 samples for CIN 2, 18 samples for CIN 3, and 19 samples as controls. Demographicprofiles and risk factors assesment, histopathologic examination, HPV DNA tests, immunocytochemistry (ICC)and immunohistochemistry (IHC) staining for survivin expression were performed on all samples. Data wasanalyzed with bivariate and multivariate analysis. <br /><strong>Results</strong>: Multivariate analysis revealed significant riskfactors for developing precancerous cervical lesions are age <strong>Conclusions</strong>: Determination of survivin expression by immunocytochemistrystaining, along with other significant risk factors, can be used in a scoring system to predict the progressivity ofCIN lesions. Application of this scoring system may be beneficial in determining the action of therapy towardsthe patient.