The association between serum lipids profile and HbA1c in type 2 diabetes mellitus in Tehran, Iran

Abstract

<strong>Background and aims:</strong> Dyslipidemia is one of the major factors implicated in the development of the vascular complications of diabetes. In this study, it was evaluated the association between serum lipids profile and Hemoglobin A_1c (HbA_1c) in type 2 diabetes mellitus.<br /> <strong>Methods:</strong> In this cross-sectional study, the serum lipid profile and HbA_1c was studied on 562 Iranian patients who were older than 30 years and had type 2 diabetes identified from the diabetes and metabolic diseases clinic of endocrinology and metabolism research institute. A Multiple Linear Regression analysis was also done with the HbA_1c as outcome variable and serum lipids profile as predictor variables; adjusted for potential confounders (age, sex, diabetes duration and Body Mass Index (BMI)).<br /> <strong>Results:</strong> In 1966, 6.34% of the national total population was over 60 years compared to mean age of the participants that was 61.6±10.4 years, with a range of 32 to 89 years. The results confirmed that the Triglyceride (TG) (β: 0.11, 95% CI: 0.000-0.004, P=0.01) and cholesterol (β: 0.13, 95% CI: 0.000-0.009, P=0.04) were correlated with the HbA_1c value but there were no significant association between HDL and LDL.<br /> <strong>Conclusion:</strong> This study demonstrated that in persons with type 2 Diabetes Mellitus (DM), HbA_1c value is a good predictor of lipid profile. Therefore, lipid profiling for all persons with type 2 DM should be a routine test.