An Interleukin-6 Single Nucleotide Polymorphism and Susceptibility to Prostate Adenocarcinoma and Bone Metastasis in an Iranian Population

Abstract

Objective: Interleukin-6 (IL-6) is an inflammatory cytokine shown to be a strong factor for growth, proliferation and<br />metastasis with many malignancies. The promoter single nucleotide polymorphism (SNPs) -174G>C (rs1800795) can<br />alter the transcriptional pattern of this gene. The present study was aimed at assessing effects of the IL-6 (rs1800795)<br />SNP on risk of benign prostate hyperplasia (BPH) and prostatic adenocarcinoma (PCa). Methods: The project was<br />performed on 112 men with PCa, 118 with BPH and 250 healthy controls. After DNA extraction, genotyping of IL-6<br />(rs1800795) was performed using PCR TaqMan Allelic Discrimination (ABI MGB). Results: The G allele frequency<br />for rs1800795 of the IL-6 gene was 74.1%, 68.6% and 67% in PCa patients, BPH patients and healthy men, respectively.<br />PCa and control groups showed significant differences (P =0.030, OR = 1.73, 95% CI: 1.05-2.21). The GG genotype<br />was more frequent in the PCa group, whereas the GC genotype was more common in the BPH in comparison to other<br />groups. Conclusion: The current study identified IL-6 -174G>C (rs1800795) as a significant predictor of susceptibility<br />for prostate cancer and bone metastasis in a northwest Iranian population.