Increased UGT1A3 and UGT1A7 Expression is Associated with Pancreatic Cancer

Abstract

UGT1A play important roles in the glucuronidation of a variety of endogenous and exogenous compounds.UGT1A isoforms are expressed tissue specifically. The aim of this study was to examine the relationship betweenUGT1A3 and UGT1A7 mRNA expression and pancreatic cancer. Paired healthy and tumor tissue samples of43 patients with pancreatic cancer were included in this study. UGT1A3 and UGT1A7 mRNA expressions wereanalyzed by real time-PCR. In the result of study, UGT1A3 and UGT1A7 mRNA expressions were significantlyhigher in tumor tissue than normal tissue of pancreatic cancer patients (p<0.05). In addition, high mRNAexpression of UGT1A3 and UGT1A7 was significantly associated with larger tumor size (p<0.05). The datasuggested that UGT1A3 and UGT1A7 may play roles in the progression of pancreatic cancer. Consequently,UGT1A3 and UGT1A7 are potential prognostic indicators.