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      •   صفحهٔ اصلی
      • نشریات انگلیسی
      • Asian Pacific Journal of Cancer Prevention
      • Volume 20, Issue 5
      • مشاهده مورد
      •   صفحهٔ اصلی
      • نشریات انگلیسی
      • Asian Pacific Journal of Cancer Prevention
      • Volume 20, Issue 5
      • مشاهده مورد
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      Evaluation of the Dwell-Time and Dose Difference in Intravesical Bacillus Calmette-Guèrin Therapy

      (ندگان)پدیدآور
      Nagai, TakashiOkamura, TakehikoTanaka, YutaroMoritoki, YoshinobuKobayashi, DaichiKobayashi, TakahiroAkita, HidetoshiYasui, Takahiro
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      اندازه فایل: 
      406.7کیلوبایت
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      نوع مدرک
      Text
      Research Articles
      زبان مدرک
      English
      نمایش کامل رکورد
      چکیده
      Objective: Bacillus Calmette-Guèrin (BCG) intravesical therapy is currently established using a low dose becauseof the high incidence of side-effects. Moreover, shortening the dwell time of BCG is conducted in some facilities owingto the complications associated with a long dwell time after injection. The method of BCG administration varies ineach facility and even with each doctor. We evaluated whether the dwell-time and dose differences in patients whounderwent intravesical BCG therapy is related to completion rates, adverse effects, and nonrecurrence rates. Methods:From November 2006 to April 2016, a total of 173 patients who received intravesical BCG therapy after transurethralresection of bladder tumor or transurethral biopsy were evaluated retrospectively. We allocated them into 4 groups basedon the dose (40 or 80 mg BCG) and the dwell time (1 or 2 hours). Completion rate, side effects, and nonrecurrencerates were evaluated. Results: No significant improvement in the completion rate or reduction in side-effects wasobserved in any of the regimens. Although nonrecurrence rates for the 1-hour dwell time tended to be lower than the2-hour dwell time, the difference was not significant. Conclusion: Our study suggests that reducing the BCG dose orshortening the dwell time does not reduce adverse effects or affect the nonrecurrence rate.
      کلید واژگان
      BCG
      dwell-time difference
      dose difference
      General Oncology

      شماره نشریه
      5
      تاریخ نشر
      2019-05-01
      1398-02-11
      ناشر
      West Asia Organization for Cancer Prevention (WAOCP)
      سازمان پدید آورنده
      Department of Urology, Anjo Kosei Hospital, 28 Higashihirokute, Anjo-cho, Anjo, Japan.
      Department of Urology, Anjo Kosei Hospital, 28 Higashihirokute, Anjo-cho, Anjo, Japan.
      Department of Urology, Anjo Kosei Hospital, 28 Higashihirokute, Anjo-cho, Anjo, Japan.
      Department of Urology, Anjo Kosei Hospital, 28 Higashihirokute, Anjo-cho, Anjo, Japan.
      Department of Urology, Anjo Kosei Hospital, 28 Higashihirokute, Anjo-cho, Anjo, Japan.
      Department of Urology, Anjo Kosei Hospital, 28 Higashihirokute, Anjo-cho, Anjo, Japan.
      Department of Urology, Anjo Kosei Hospital, 28 Higashihirokute, Anjo-cho, Anjo, Japan.
      Department of Nephro-Urology, Nagoya City University, Graduate School of Medical Sciences, Kawasumi 1, Mizuho-cho, Mizuho-ku, Nagoya, Japan.

      شاپا
      1513-7368
      2476-762X
      URI
      https://dx.doi.org/10.31557/APJCP.2019.20.5.1389
      http://journal.waocp.org/article_87913.html
      https://iranjournals.nlai.ir/handle/123456789/33259

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