Association of Dietary Intake Ratio of n-3/n-6 Polyunsaturated Fatty Acids with Breast Cancer Risk in Western and Asian Countries: A Meta-Analysis

Abstract

Objective: This systematic review and meta-analysis were performed to determine association of dietary intake ratio<br />of n-3/n-6 polyunsaturated fatty acids with breast cancer risk in Western and Asian countries. Methods: The authors<br />conducted a meta-analysis of published research articles on association of dietary intake ratio of n-3/n-6 polyunsaturated<br />fatty acids (PUFAs) with breast cancer risk in Western and Asian countries published between January 2000 and February<br />2019 in online article databases of PubMed, ProQuest and EBSCO. Pooled risk ratios (RR) were calculated using<br />fixed and random-effect models. Publication bias was visually evaluated by performing funnel plots and statistically<br />assessed by Egger's and Begg's tests. Data were processed by using Stata version 14.2 (Stata Corporation). Results:<br />This study reviewed 913 articles. There were 13 studies included in systematic review continued by meta-analysis<br />of relevant data with total number of samples: 275,264 patients. The results showed dietary intake ratio of n-3/n-6<br />PUFAs with breast cancer risk in Western and Asian countries (RR = 0.99; 95% CI: 0.92-1.07). Dietary intake ratio<br />of n-3/n-6 PUFAs with breast cancer risk in Western countries reached (RR = 0.98; 95% CI: 0.91-1.06) and there was<br />any significant publication bias for studies included. Dietary intake ratio of n-3/n-6 PUFAs with breast cancer risk in<br />Asian countries reached (RR = 1.18; 95% CI: 0.94-1.47) and there was not any significant publication bias for studies<br />included. Conclusion: This analysis confirmed association of dietary intake ratio of n-3/n-6 PUFAs with breast cancer<br />risk in Western and Asian countries. Higher dietary intake ratio is associated with lower risk of breast cancer in Asian<br />countries rather than Western countries. This study suggests increasing dietary intake ratio n-3/n-6 PUFAs will provide<br />benefit for breast cancer prevention.