Evaluation of distribution of genetic polymorphism CYP2D6*10 in tramadol poisoning with seizure: A Case-Control study

Abstract

Tramadol overdose is inappropriately prevalent in Iran and is one of the most common causes of hospital admissions in recent years. Tramadol is both a codeine family and a weak opioid receptor agonist (AG) that is used at regular doses as an analgesic and may lead to seizures. The aim of this study was to investigate the relationship between physiological effects of high dose tramadol administration and cytochrome c enzyme gene polymorphism.<br /> CYP2D6) p450) in patients with tramadol intoxication referring to the poisoning ward of Razi Hospital, Ghaemshahr city,Mazandaran province was surveyed.<br /> This cross-sectional study was performed on 121 patients admitted for poisoning ward of Tramadol only in 2016. Also, these patients do not have any previous underlying diseases such as cardiac and renal complications, etc. 60 of the patients had seizure due to tramadol. At first, demographic characteristics of patients and factors evaluated were extracted in a questionnaire and ml of each patient.<br /> 5th was taken blood. After preparing the samples, RFLP - PCR was used to evaluate the CYP2D6 gene polymorphism (rs1065852). The mean age of patients was 25 years. 78% of them were smokers. Statistical methods were considered as p