The Effect of HLA-DRB1 on Cholecystitis

Abstract

<b>Background</b>: Cholecystitis is one of the major digestive diseases. Its prevalence is particularly high in some populations. Significant risk factors associated with cholecystitis include age, sex, obesity, diet, parity and type 2 diabetes. <br/><b>Objective</b>: To determine the association between HLA-DRB1 and cholecystitis. <br/><b>Methods</b>: This casecontrol study included forty Iraqi Arab patients who had cholecystitis with multiple calculi treated by cholecystectomy admitted in the surgical ward at Al-Kindy Teaching Hospital Baghdad between September -2013 to June -2014. The control group consisted of forty healthy volunteers among the staff of Al-Kindy College of Medicine. Control and cholecystitis patients groups were typed for identifying the DRB1* alleles using DNA-based methodology (PCR-SSOP). <br/><b>Results</b>: There was an increased frequency of HLA-DRB1*0301 in patients with cholecystitis compared with healthy controls (p=0.0442, odd ratio=4.1111, 95% CI: 1.0372-16.2949). <br/><b>Conclusion</b>: HLADRB1*0301, as a genetic factor, seems to have an association with cholecystitis.