• Identical Twins with a Mutation in the STK4 Gene Showing Clinical Manifestations of the Mutation at Different Ages: A Case Report 

  Abolnezhadian, Farhad؛ Iranparast, Sara؛ Ahmadpour, Fatemeh (Shiraz Institute for Cancer Research, 2020-12-01)

  Combined immunodeficiencies (CIDs) are a heterogeneous group of disorders characterized by various gene mutations. The mutations in the STK4 (Serine Threonine Kinase 4) gene, which has a role in the regulation of apoptosis ...

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• Serum Level of Soluble Lymphocyte-Activation Gene 3 Is Increased in Patients with Rheumatoid Arthritis 

  Saadati, Nayyereh؛ khodashahi, Mandana؛ Rezaieyazdi, Zahra؛ Sahebari, Maryam؛ Saremi, Zeinab؛ Mohammadian Haftcheshmeh, Saeed؛ Rafatpanah, Houshang؛ Salehi, Maryam (Shiraz Institute for Cancer Research, 2020-12-01)

  Background: Rheumatoid arthritis (RA) is described as a systemic and chronic autoimmune disease characterized by inflammatory polyarthritis. Lymphocyte-activation gene 3 (LAG3) is a membrane glycoprotein expressed on ...

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• Toll-Like Receptor (TLR)-9 rs352140 Polymorphism is an Immunopathology Protective Factor in Parkinson's Disease in the Northern Iranian Population 

  Miri, Niloufar Sadat؛ Saadat, Payam؛ Azadmehr, Abbas؛ oladnabi, morteza؛ Daraei, Abdolreza (Shiraz Institute for Cancer Research, 2020-12-01)

  Background: Neuroinflammation and immunopathology in Parkinson's disease (PD) is believed to be associated with genetic and environmental factors. Objective: We conducted the current study to evaluate the Toll-like receptors ...

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• Glucocorticoids Regulate the Activation of Neutrophils and Inhibit the Formation of Pulmonary Embolism 

  Meng, Zhefeng؛ Sun, Keyu؛ Xie, Zichen؛ Li, Yang؛ Li, Yanyan؛ Song, Jianfeng (Shiraz Institute for Cancer Research, 2020-12-01)

  Background: There is a close relationship between neutrophil extracellular traps (NETs) and venous thromboembolism (VTE), and the regulatory role and mechanism of glucocorticoids (GC) in the formation of NETs are unclear. ...

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• Identification of Functional Fragments in gMYL6 and the Mechanism of Improving NK Cell-Mediated Cytotoxicity 

  Ji, Yuying؛ Cao, Rui؛ Lv, Guangxin؛ Jin, Yuanyuan؛ Chen, Jing (Shiraz Institute for Cancer Research, 2020-12-01)

  Background: In a previous study, unrecognized role of gMYL6 in the up-regulation of human NK cells development and cytotoxicity was reported. Objective: To further elucidate the mechanism of action of small fragments ...

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• Clinical Efficacy of Vitamin D3 Adjuvant Therapy in Allergic Rhinitis: A Randomized Controlled Trial 

  Liu, Xiaoling؛ Liu, Xiaojia؛ Ren, Yu؛ Yang, Hongxin؛ Sun, Xiaolei؛ Huang, Haiyun (Shiraz Institute for Cancer Research, 2020-12-01)

  Background: Vitamin D supplementation has been proven to be effective in the treatment of allergic rhinitis (AR). Objective: We conducted the present study to explore the role and efficacy of vitamin D adjuvant therapy for ...

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• Interleukin-27 Suppresses T Helper-17 Inflammation in Allergic Rhinitis 

  Ouyang, Hong؛ Cheng, Jie؛ Du, Jingdong؛ Gan, Huiyun؛ Lu, Zheng (Shiraz Institute for Cancer Research, 2020-12-01)

  Background: T helper 17 (Th17) cells and the related cytokines, interleukin (IL)- 17 and IL-23, were proved to play pivotal roles during the development of allergic rhinitis (AR). IL-27, an anti-inflammatory cytokine, has ...

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• DNA Based Vaccines against Mycobacterium Tuberculosis: Recent Progress in Vaccine Development and Delivery System 

  Mobed, Ahmad (Shiraz Institute for Cancer Research, 2020-12-01)

  Tuberculosis (TB) is believed to be one of the leading causes of death in the world; nevertheless, Bacillus Calmette-Guérin (BCG) is the solitary vaccine utilized to prevent TB. Despite the protective effect of this vaccine ...

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• Plasmodium Vivax Malaria: Usual Illness with Dysregulated Immune Profile 

  Gupta, Richa؛ Dixit, Sonali؛ Garg, Neha؛ Kotru, Mrinalini (Shiraz Institute for Cancer Research, 2020-09-01)

  Afebrile Plasmodium vivax disease is believed to be extremely rare; and so is the association of a secondary immune thrombocytopenia due to Plasmodiun vivax malaria. This is a case of malaria presenting in an atypical ...

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• Importance of MMP-8 in Salivary and Gingival Crevicular Fluids of Periodontitis Patients 

  Fatemi, Kazem؛ Rezaee, Seyed Abdolrahim؛ Banihashemrad, Seyed Ali؛ Keyvanfar, Sanaz؛ Eslami, Meghdad (Shiraz Institute for Cancer Research, 2020-09-01)

  Background: Matrix metalloproteinases (MMPs) stimulate alveolar bone loss in chronic periodontitis. Objective: To evaluate the salivary and gingival crevicular fluid (GCF) levels of MMP-8 in patients with moderate to severe ...

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• A Patient with CTLA-4 Haploinsufficiency with Multiple Autoimmune Presentations: A Case Report 

  Zaremehrjardi, Fatemeh؛ Baniadam, Leila؛ Seif, Farhad؛ Arshi, Saba؛ Bemanian, Mohamad Hasan؛ Shokri, Sima؛ Rezaeifar, Afshin؛ Fallahpour, Morteza؛ Nabavi, Mohammad (Shiraz Institute for Cancer Research, 2020-09-01)

  Increased susceptibility to autoimmunity, malignancy, and allergy in addition to recurrent infections are the main characteristics suggesting for the primary immunodeficiency diseases (PID). CTLA-4 is predominantly expressed ...

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• Hereditary Angioedema Due to C1-Inhibitor Deficiency in Romania: First National Study, Diagnostic and Treatment Challenges 

  Gabos, Gabriella؛ Nadasan, Valentin؛ Mihaly, Eniko؛ Dobru, Daniela (Shiraz Institute for Cancer Research, 2020-09-01)

  Background: Hereditary angioedema (HAE) is a rare genetic potentially life-threatening disease characterized by episodic non-pruritic subcutaneous and submucosal edema attacks in different parts of the body. Objective: To ...

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• Association of rs11558471 in SLC30A8 Gene with Interleukin 17 Serum Levels and Insulin Resistance in Iranian Patients with Type 2 Diabetes 

  Ahmadi, Mehran؛ Mahrooz, Abdolkarim؛ abediankenari, saeid؛ Hayati Roodbari, Nasim (Shiraz Institute for Cancer Research, 2020-09-01)

  Background: Functional single nucleotide polymorphisms in zinc transporter 8 (ZnT8) gene may be key determinants of humoral autoreactivity to ZnT8. Objective: The present study is expected to provide new information on the ...

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• Variants in Intron 4 of PD-1 Gene are Associated with the Susceptibility to SLE in an Iranian Population 

  Khanjari, Yousef؛ Oladnabi, Morteza؛ Abdollahi, Nafiseh؛ Heidari, Ahmad؛ Mohammadi, Saeed؛ Tabarraei, Alijan (Shiraz Institute for Cancer Research, 2020-09-01)

  Background: Programmed cell death protein 1 (PD-1) is a negative costimulatory molecule with immunomodulatory properties. Recently, PD-1 gene defects have attracted attention in the pathogenesis of SLE. Objective: Here, ...

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• IL-6 and IL-10 Closely Correlate with Bacterial Bloodstream Infection 

  Guan, Jingjing؛ Wang, Zhongyong؛ Liu, Xiaoyuan؛ Jiang, Yujie؛ Gao, Qiuqi؛ Wu, Qing؛ Lu, Hong؛ Wu, Lianfeng؛ Zhang, Zhuo؛ Lin, Xiangyang؛ Qian, Jingjing (Shiraz Institute for Cancer Research, 2020-09-01)

  Background: Given the high mortality of bacterial bloodstream infections (BSI), blood culture results do not meet clinical needs timely due to being time-consuming and having low positive rate. Whether we can identify the ...

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• Effects of Long-time Exposure to Lipopolysaccharide on Intestinal Lymph Node Immune Cells and Antibodies Level in Mice 

  Wu, Chenchen؛ Li, Chao؛ Ma, Dexue؛ Zhang, Mingming؛ An, Liyan؛ zhou, hongchao (Shiraz Institute for Cancer Research, 2020-09-01)

  Background: Endotoxin, widely present in the living environment of humans and animals, leads to endotoxemia during a short period. However, the long-term effects of endotoxin on immune function are unclear. Objective: To ...

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• Importance of L. Infantum H2B Recombinant Antigen for Serodiagnosis of Visceral Leishmaniasis 

  Rezaei, Zahra؛ Pouladfar, Gholamreza؛ Ramezani, Amin؛ Mostafavi-Pour, Zohreh؛ Abbasian, Amin؛ Sarkari, Bahador؛ Pourabbas, Bahman (Shiraz Institute for Cancer Research, 2019-12-01)

  Background: Visceral leishmaniasis (VL) can lead to death in more than 95% of cases if left untreated. Accurate and early diagnosis has an important role in reducing mortality rate of this disease. ...

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• Circulating Levels of Pro-inflammatory Cytokines in Patients with Nonalcoholic Fatty Liver Disease and Non-Alcoholic Steatohepatitis 

  Hadinia, Abolghasem؛ Doustimotlagh, Amir Hossein؛ Goodarzi, Hamed Reza؛ Arya, Arash؛ Jafarinia, Mojtaba (Shiraz Institute for Cancer Research, 2019-12-01)

  Background: Pro-inflammatory cytokines are associated with systemic inflammatory responses. Objective: To investigate the levels of pro-inflammatory cytokines (IL-1b, IL-6, and TNF-a) in ...

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• IL-25 and IL-33 Serum Levels are not Associated with the Type of Allergen Causing Allergic Rhinitis 

  Abbasi, Reza؛ Zomorodian, Kamiar؛ Zare Shahrabadi, Zahra؛ Saadat, Farshid؛ Nabavizadeh, Seyed Hesamedin؛ Esmaeilzadeh, Hossein؛ Alyasin, Sohila (Shiraz Institute for Cancer Research, 2019-12-01)

  Background: Fungal aeroallergens might sensitize the airway which in turn produces a specific cytokine profile. Objective: To evaluate the IL-25 and IL-33 profile in patients with fungal ...

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• Decreased Level of IL-37 Correlates Negatively with Inflammatory Cytokines in Cerebrospinal Fluid of Patients with Neuro-Behcet’s Disease 

  Ben Dhifallah, Imene؛ Borhani-Haghighi, Afshin؛ Hamzaoui, Agnes؛ Hamzaoui, Kamel (Shiraz Institute for Cancer Research, 2019-12-01)

  Background: Behçet's disease (BD) is a systemic inflammatory disease with a chronic, relapsing-remitting course of unknown etiology. Neuro-Behcet's disease (NBD) induce serious CNS complications and are ...

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