Nasopharyngeal Carcinoma Protein Interaction Mapping Analysis via Proteomic Approaches

Abstract

Nasopharyngeal carcinoma (NPC), although not very common in many parts of the world, is a major concern in<br />some countries, including Iran. Molecular studies are very helpful to provide essential information regarding underlying<br />carcinogenetic mechanisms. Here, considering NPC proteomic approaches, established biomarkers were designated for<br />protein-protein interaction network construction and analysis with corresponding plug-ins. A network of reported protein<br />markers was constructed and topological and biological process features were investigated. Centrality analysis showed<br />that JUN, CALM1, HSB1, and SOD1 are more important than other differentially expressed proteins in an interacting<br />pattern. What is more, by extending the network, Tp53, PRDM10, AKT1, ALB, HSP90AA1, and EGFR achieved the<br />highest values for NPC network strength. It can be concluded that these proteins as well as their contributing processes,<br />particularly in a second network, may be important for NPC onset and development. Targeting these candidate proteins<br />may allow novel treatment approaches following appropriate validation.