Prevalence of Anti-Erythrocyte Alloantibodies and Relevant Factors among the Patients with Thalassemia Major in Kermanshah, Iran

Abstract

<strong><em><span>Background</span></em></strong><br /> <span lang="EN">The major treatment for</span><span> thalassemia </span><span lang="EN">is a transfusion. The present study aimed to determine the frequency of </span><span>erythrocyte alloantibodies</span><span lang="EN"> and the relevant factors among the patients with thalassemia major in Kermanshah city, Iran.</span><br /> <strong><em><span>Materials and Methods: </span></em></strong><span lang="EN">This</span><span lang="EN">cross-sectional study was performed on 218 thalassemia major patients with 2-48 years old, referred to thalassemia boarding clinic at the Dr. Mohammad Kermanshahi Hospital in Kermanshah city, Iran. Blood samples from thalassemia patients (</span><span>5 ml) </span><span lang="EN">were examined in terms of the presence of </span><span>erythrocyte</span><span lang="EN"> antibodies (using the screening antibody test), and additional information including age, blood </span><span>Rh</span><span lang="EN">, spleen status was extracted from the patients' </span><span>profile</span><span lang="EN">. The information was finally analyzed using SPSS software version 20.0.</span><br /> <strong><em><span>Results: </span></em></strong><span lang="EN">A total of 74 patients (33.9%) had alloantibody, and 144 (67.1%) lacked antibody. The mean age of the subjects was 21.85</span><span lang="FA" dir="RTL">±</span><span lang="EN">8.083 years. The oldest and youngest subjects were 48 and 2 years old, respectively. The sample population included 114 men (52.3%) and 104 women (47.7%).<span> </span>35.8% of the patients underwent splenectomy. There was no significant relationship between blood Rh, spleen status, and incidence of alloantibodies </span><span>(all P> 0.05)</span><span lang="EN">.</span><br /> <strong><em><span>Conclusion</span></em></strong><br /> <span lang="EN">The high prevalence of Alloimmunization in the present study requires a more detailed examination of donated blood for compatibility of </span><span>main </span><span lang="EN">and sub blood groups.</span>