Comparison of Restricted Fluid Volume with Standard Fluid Volume in Management of Transient Tachypnea of the Newborns: A Randomized Controlled Trial

Abstract

<strong><em><span style="font-family: Times New Roman;">Background</span></em></strong><br /> <span style="font-family: Times New Roman;">Transient tachypnea of the newborn (TTN) is one of the most common neonatal respiratory disease and its symptoms usually begins in the first few hours after birth. The volume of fluid intake according to the neonate's conditions varies. <span style="font-size: medium;">We aimed</span> to compare the restricted fluids volume with standard fluids volume in treatment of neonates with TTN.</span><br /> <span style="font-family: Times New Roman;"><strong><em>Materials and Methods: </em></strong>This clinical trial was performed on 80 neonates with a diagnosis of TTN admitted in the Neonatal intensive care unit <span style="font-size: medium;">(NICU) </span>of Fatemiyeh <span style="font-size: medium;">H</span>ospital and Beasat <span style="font-size: medium;">Hospital</span> of Hamadan Medical University in Iran<span style="font-size: medium;">.</span> Patients were randomly divided to standard fluids volume (control = 40)<span style="font-size: medium;">,</span> and restricted fluids volume treatment groups (case = 40). The hospitalization duration, oxygen therapy duration as well as the number of days need for oxygen with <span style="font-size: medium;">hood;</span> Nasal continuous positive airway pressure (NCPAP)<span style="font-size: medium;">,</span> and mechanical ventilation therapy <span style="font-size: medium;">was</span> recorded. After data collection, the data were statistically analyzed via SPSS <span style="font-size: medium;">software (</span>version 21<span style="font-size: medium;">.0)</span>.</span><br /> <span style="font-family: Times New Roman;"><strong><em>Results: </em></strong>The subjects were 30 (37.5%) females and 50 (62.5%) males (62.5%) with an average gestational age of 38.12(±1.07) weeks.The main aim from this interventional study was effect of restricted fluidtherapy on management of TTN in NICU section. The hospitalization duration, oxygen therapy duration and need for oxygen therapy with hood in the intervention group were significantly lower than the control group (P<0.05), but need for mechanical ventilation and need for NCPAP were not significantly different between the two groups (P>0.05). </span><br /> <strong><em><span style="font-family: Times New Roman;">Conclusion</span></em></strong><br /> <span style="font-family: Times New Roman;">TTN treatment with restricted fluids volume, compared with standard volume of fluids, significantly reduces the need for respiratory supports as well as the duration of hospitalization in the NICU section. </span>