IL-1B (C+3954T) Gene Polymorphism and Susceptibility to Gastric Cancer in the Iranian Population

Abstract

<b>Background:</b> Gastric cancer as one of the most important diseases affecting health in all worldwide. Currentstudies have confirmed associations of cytokine gene polymorphisms with the risk of gastric cancer development.The current research aimed to assess the association of IL-1B+3954 genotypes with the risk of gastric cancerin the Iranian population. Materials and <br/><b>Methods</b>: This case-control study covered 49 gastric cancer patientscompared to 53 cancer free individuals as a control group. Genomic-DNA extraction was carried out from biopticsamples of patients and peripheral blood of healthy volunteers. Polymorphism of IL-1B +3954 genotypes wereanalysed with a polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method.<br/><b>Results</b>: The frequencies of IL-1B +3954 A1A1, A1A2 and A2A2 genotypes in healthy individuals were 26.4, 66and 7.6 %, respectively. However, in gastric cancer patients, A1A1, A1A2 and A2A2 with 4.1, 51 and 44.9% wereobserved (p<0.05). <br/><b>Conclusions</b>: The findings of our results show a positive association between the IL-1B+3954genotype distribution and the risk of gastric cancer disease in the Iranian population.