Association of Warfarin Therapy with <i>APOE</i> and <i>VKORC1</i> Genes Polymorphism in Iranian Population

Abstract

Warfarin is a vitamin K antagonist that genetic and non-genetic factors affected on its doserequirement in the patients with cardio vascular disease. The aim of this study was whetherthe APOE and VKORC1 polymorphisms influence on warfarin dose requirements in the partof Iranian patients. Blood samples were collected from 86 warfarin-treated patients. Afterextraction of genomic DNA, the VKORC1 (rs9923231) and the APOE (rs429358 and rs7412)polymorphisms were genotyped by PCR-RFLP technique. We found that the Iranian patientscarrying genotypes GA or AA of VKORC1 polymorphism tended to receive lower dose ofwarfarin (p = 0.018). Furthermore, the E3/E3 genotype was observed with the frequency morethan 60% in the patients with low dose of warfarin. The BMI and weight also showed a positivecorrelation with warfarin dose. However, it was not statistically significant (p > 0.05). Theresults of this study may be useful in defining of warfarin dose algorithms for Iranian patients.