Cytokine Indexes in Pemphigus Vulgaris: Perception of Its Immunpathogenesis and Hopes for Non-Steroidal Treatment

Abstract

Pemphigus vulgaris (PV) is a chronic autoimmune blistering disease of the skin, in whichloss of adhesion between keratinocytes is caused by autoantibodies. It has been hypothesizedthat cytokines play an essential role in the pathogenesis of PV. This study aimed to investigatethe other immunopathological aspects of PV by determining the serum levels of cytokines inPV patients to find another treatment strategy except corticosteroid therapy.Twenty-three patients with PV and a control group consisting of 24 healthy subjects werestudied. Interleukin (IL)-2, IL-4, IL-6, IL10, IL-12, IL-17 and interferon-gamma (IFN-γ) weremeasured in the sera of patients by the enzyme-linked immunosorbent assay (ELISA) method.The serum levels of IL-2, IL-4, IL-17 and IFN-γ in most patients and controls wereundetectable. The serum concentrations of IL-10 in the patients and controls were undetectable,nevertheless, the mean serum levels of this cytokine was 64.375 pg/mL in four patients. Themean serum levels of pro-inflammatory cytokine IL-6 increased significantly in the patients,compared to the controls (169.50 vs. 75.62 pg/mL) (P < 0.05). The same was observed foranother pro-inflammatory cytokine, IL-12 (135.33 vs. 86.28 pg/mL) (P < 0.05).Based on the results of this study it can be concluded that the Type 2 T helper cytokine(IL-6) and macrophage-derived cytokine (IL-12) have essential roles in PV pathophysiology.In addition, the potential clinical application of Th1/Th2 type cytokine-based therapy in PVshould be considered in next studies.